Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00188864
Status:
COMPLETED
Last Update Posted:
2019-11-27
First Post:
2005-09-12
Brief Title:
Dexamethasone for Palliation - Brain Metastases
Sponsor:
University Health Network Toronto
Organization:
University Health Network Toronto
Study Overview
Official Title:
Dexamethasone as Palliative Treatment in Addition to Radiation Therapy for Patients With Brain Metastases A Prospective Study
Status:
COMPLETED
Status Verified Date:
2019-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Brain metastases occur when cancer cells from the initial tumour site for example lung or breast spread to the brain This develops in approximately 10 - 30 of adults with cancer They can produce different complaints related to their effect on brain functioning decrease in a persons ability to carry on with their usual activities a reduction in the quality of life and shortened life expectancy
The standard treatment particularly for people with more than one brain metastasis consists of palliative radiation therapy to the brain and steroids Steroids such as Decadron or Dexamethasone are medication used to reduce swelling around the tumour and thus symptoms improve Steroids could be very helpful but have a number of potential side effects particularly if used for longer periods of time There is no standard dose of Decadron used in treating brain metastases patients The most commonly dose used is 4 mg four timesday
This study will assess if lower doses of Decadron - 8 mg every morning for symptomatic patients and 4 mg every morning for asymptomatic patients - are effective in maintaining symptom control in patients with brain metastases without neurological deterioration that necessitates the patient to go back or to a higher dose at any time This information will help also in understanding how to decrease the side effects associated with higher doses of steroids in people with your condition
The standard treatment particularly for people with more than one brain metastasis consists of palliative radiation therapy to the brain and steroids Steroids such as Decadron or Dexamethasone are medication used to reduce swelling around the tumour and thus symptoms improve Steroids could be very helpful but have a number of potential side effects particularly if used for longer periods of time There is no standard dose of Decadron used in treating brain metastases patients The most commonly dose used is 4 mg four timesday
This study will assess if lower doses of Decadron - 8 mg every morning for symptomatic patients and 4 mg every morning for asymptomatic patients - are effective in maintaining symptom control in patients with brain metastases without neurological deterioration that necessitates the patient to go back or to a higher dose at any time This information will help also in understanding how to decrease the side effects associated with higher doses of steroids in people with your condition
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None