Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00180804
Status:
COMPLETED
Last Update Posted:
2023-10-16
First Post:
2005-09-13
Brief Title:
Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
Combination of Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages
Status:
COMPLETED
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
For implantation of developing conceptus placental cells need to invade mothers uterus to access maternal blood supply in a control manner We have found a combination of maternal immune genes the KIR family and fetal genes HLA-C strongly associated with pre-eclampsia where placenta does not implant adequately The aim of this research is to investigate these two genes family in women suffering with recurrent miscarriages and find a possible link between them
Detailed Description:
Little is known about reasons for early pregnancy failures It is believed that some pathology leading to defective implantation of fetus in maternal uterus may lead to recurrent early miscarriages This project arises from previous work on pre-eclampsia where we found combination of maternal immune genes KIR with their ligand HLA-C in the fetus was strongly associated with the disease We will tissue type the fetus mother and father in cases of unexplained miscarriages We hope that genetic findings in recurrent miscarriage will lead to new insights prevention and treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None