Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00180648
Status:
COMPLETED
Last Update Posted:
2016-02-22
First Post:
2005-09-12
Brief Title:
Plasma Determination of Glucagon-like Peptide 2 as a Predictor of Recovery in Adults With Acute Intestinal Failure
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
Plasma Determination of Glucagon-like Peptide 2 as a Predictor of Recovery in Adults With Acute Intestinal Failure
Status:
COMPLETED
Status Verified Date:
2008-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate the theory that the plasma level of Glucagon like peptide 2 GLP-2 in patients with intestinal failure can predict their clinical recovery
Detailed Description:
When major segments of small bowel have been removed surgically or damaged by disease the length of the residual bowel may be inadequate to maintain overall nutrition and the net result is described as intestinal failure
Without medical intervention patients with intestinal failure become malnourished and dehydrated because their remaining intestine is unable to absorb enough water vitamins and other nutrients from the ingested food Intravenous feeding offers life saving treatment but causes complications like infections and liver problems It also poses enormous strain on day to day life
Glucagon like peptide 2 GLP-2 is a naturally occurring hormone or chemical messenger that is able to increase the surface area of the intestinal lining or mucosal mass and the absorptive efficiency of the remaining intestine
Intestinal failure patients in whom not only parts of the small bowel but also the large bowel have had to be surgically removed have been shown to have a markedly impaired rise in GLP-2 levels following meals in contrast to patients with a preserved large bowel who have increased levels of GLP-2 and are known to have much better functional adaptation
From this we hypothesise that the GLP-2 level is directly related to and could predict clinical recovery in intestinal failure as measured by Amount of parenteral nutrition required Length of hospital stay Mortality
We also aim to compare GLP-2 levels of patients with acute intestinal failure with that of patients with chronic intestinal failure as well as healthy controls
Without medical intervention patients with intestinal failure become malnourished and dehydrated because their remaining intestine is unable to absorb enough water vitamins and other nutrients from the ingested food Intravenous feeding offers life saving treatment but causes complications like infections and liver problems It also poses enormous strain on day to day life
Glucagon like peptide 2 GLP-2 is a naturally occurring hormone or chemical messenger that is able to increase the surface area of the intestinal lining or mucosal mass and the absorptive efficiency of the remaining intestine
Intestinal failure patients in whom not only parts of the small bowel but also the large bowel have had to be surgically removed have been shown to have a markedly impaired rise in GLP-2 levels following meals in contrast to patients with a preserved large bowel who have increased levels of GLP-2 and are known to have much better functional adaptation
From this we hypothesise that the GLP-2 level is directly related to and could predict clinical recovery in intestinal failure as measured by Amount of parenteral nutrition required Length of hospital stay Mortality
We also aim to compare GLP-2 levels of patients with acute intestinal failure with that of patients with chronic intestinal failure as well as healthy controls
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None