Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00186719
Status:
UNKNOWN
Last Update Posted:
2011-07-26
First Post:
2005-09-13
Brief Title:
How Smoking Causes COPD Examination of Immune System Changes
Sponsor:
St Josephs Healthcare Hamilton
Organization:
St Josephs Healthcare Hamilton
Study Overview
Official Title:
How Smoking Causes COPD Examination of Immune System Changes
Status:
UNKNOWN
Status Verified Date:
2011-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A breathing condition known as chronic obstructive pulmonary disease COPD caused by cigarette smoking is a major health problem The way by which smoking leads to lung disease is uncertain Recent research done in animals provides a description of specific changes that is a reduction in these immune cell types as a result of cigarette smoke exposure The study you have been asked to participate in is a pilot study to see if similar changes occur in humans who smoke The purpose of this study is to evaluate this new method of testing blood in 3 groups of 10 people normal non-smoking subjects subjects who smoke with no history of lung disease and subjects who smoke and have smoking related COPD
Detailed Description:
The mechanism by which smoking leads to damage to lung tissue in susceptible hosts is uncertain Recently there has been description of specific changes that is reduction in the number and activity of certain key immune cell types - dendritic cells- as a result of cigarette smoke exposure This work was done in animal models and we would like to develop methods that will allow us to examine if similar changes occur in humans who smoke Reduced number and activity of dendritic cells would be expected to lead to increased incidence of infection - a common problem in patients with COPD
Since dendritic cells come to the lung from the bloodstream and one can detect them in the circulation we will look at the dendritic cells that are present in the peripheral blood
Since dendritic cells come to the lung from the bloodstream and one can detect them in the circulation we will look at the dendritic cells that are present in the peripheral blood
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None