Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00180635
Status:
COMPLETED
Last Update Posted:
2019-07-10
First Post:
2005-09-09
Brief Title:
NO Donors and Inhibitors to Study Imbalance of Nitrogen Stress and Antioxidant Defense in COPD
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
A Double Blind Crossover Placebo-controlled Study to Evaluate the Effect of L-arginine and Aminoguanidine on Bronchial and Alveolar Nitric Oxide and Nitric Oxide Metabolites
Status:
COMPLETED
Status Verified Date:
2019-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The primary aim of this study is to investigate the effects of oral and inhaled administration of L-arginine and of inhaled aminoguanidine on bronchial and alveolar exhaled NO and NO metabolites in exhaled breath condensate induced sputum nasal lavage and mouth wash fluid in healthy non-smokers current smokers and patients with COPD
Detailed Description:
Nitric oxide NO is produced by resident and inflammatory cells in the respiratory tract by the enzyme NO synthase NOS which exists in three isoforms neuronal NOS nNOS inducible NOS iNOS and endothelial NOS NO production is increased in patients with COPD and the production of NO under oxidative stress conditions generates reactive nitrogen species that may amplify the inflammatory response in COPD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None