Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00007384
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-12-19
Brief Title:
Longitudinal LDL-C Studies in Black and White Families
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To longitudinally investigate multigenerational familial clustering of plasma low density lipoprotein cholesterol LDL-C with particular emphasis on the influences of apoE genotypes and various behaviors
Detailed Description:
BACKGROUND
Elevated concentrations of plasma low density lipoprotein cholesterol LDL-C a major risk factor for coronary heart disease cluster significantly in families This clustering has been observed in cross-sectional studies in both black and white families but longitudinal data on the familial clustering of LDL-C are virtually nonexistent
DESIGN NARRATIVE
The longitudinal study will provide new and important information about changes in the familial low density lipoprotein cholesterol LDL-C correlations in black and white families from the period of shared household environments to that of separate households using families from the Princeton Lipid Research Clinics LRC Prevalence 1973-75 and Family Studies 1975-76 The study will also provide important information on changes in individual LDL-C levels over the same 25 year period The former student participants were six to 18 years of age and are now 32 to 45 years of age their parents were largely 26 to 55 years of age and are now 51 to 80 years of age Plasma LDL-C concentrations in children and adults have been shown to associate with the apolipoprotein apo E genotype with obesity and with such elective behaviors as diet cigarette smoking and physical activity In the LRC Study measurements were made of LDL-C body habitus elective behaviors and the family history of cardiovascular disease CVD The study will obtain repeat measures of these factors plus determine the apo E isoforms Changes in individual LDL-C levels and in familial associations can then be assessed in association with apo E isoforms body composition elective behaviors and family history of CVD Family members share ranges of body weight patterns of fat distribution dietary and smoking habits and physical activity levels The extent to which the familial clustering of LDL-C levels is determined by apo E isoforms interacting with the similar levels of obesity and with the similar behaviors is not currently known
Elevated concentrations of plasma low density lipoprotein cholesterol LDL-C a major risk factor for coronary heart disease cluster significantly in families This clustering has been observed in cross-sectional studies in both black and white families but longitudinal data on the familial clustering of LDL-C are virtually nonexistent
DESIGN NARRATIVE
The longitudinal study will provide new and important information about changes in the familial low density lipoprotein cholesterol LDL-C correlations in black and white families from the period of shared household environments to that of separate households using families from the Princeton Lipid Research Clinics LRC Prevalence 1973-75 and Family Studies 1975-76 The study will also provide important information on changes in individual LDL-C levels over the same 25 year period The former student participants were six to 18 years of age and are now 32 to 45 years of age their parents were largely 26 to 55 years of age and are now 51 to 80 years of age Plasma LDL-C concentrations in children and adults have been shown to associate with the apolipoprotein apo E genotype with obesity and with such elective behaviors as diet cigarette smoking and physical activity In the LRC Study measurements were made of LDL-C body habitus elective behaviors and the family history of cardiovascular disease CVD The study will obtain repeat measures of these factors plus determine the apo E isoforms Changes in individual LDL-C levels and in familial associations can then be assessed in association with apo E isoforms body composition elective behaviors and family history of CVD Family members share ranges of body weight patterns of fat distribution dietary and smoking habits and physical activity levels The extent to which the familial clustering of LDL-C levels is determined by apo E isoforms interacting with the similar levels of obesity and with the similar behaviors is not currently known
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL062394 | NIH | None | httpsreporternihgovquickSearchR01HL062394 |