Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00189358
Status:
COMPLETED
Last Update Posted:
2010-07-20
First Post:
2005-09-12
Brief Title:
A Phase II Study of ZD1839 and Tamoxifen in Patients With Epithelial Ovarian Carcinoma Cancer of the Fallopian Tube or the Peritoneum Refractory to Platinum- and Taxane-based Therapy
Sponsor:
AGO Study Group
Organization:
AGO Study Group
Study Overview
Official Title:
A Phase II Study of ZD1839 and Tamoxifen in Patients With Epithelial Ovarian Carcinoma Cancer of the Fallopian Tube or the Peritoneum Refractory to Platinum- and Taxane-based Therapy
Status:
COMPLETED
Status Verified Date:
2010-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Although initially responsive to cytoreductive surgery and platinum- andor taxane-based chemotherapy a majority of patients with epithelial ovarian cancer cancer of the fallopian tube or the peritoneum will eventually relapse Recurrence within 6 months after completing platinum-containing chemotherapy indicates a platinum-refractory cancer disease New therapeutic strategies are required in platinum-refractory disease Inhibition of growth signals induced by the epidermal growth factor receptor pathway or by the estrogen receptor pathway provides promising targets in epithelial ovarian cancer cancer of the fallopian tube or the peritoneum The trial is to evaluate the safety and tolerability of the combination of the epidermal growth facto tyrosine kinase inhibitor ZD1839 and the clinically established antiestrogen tamoxifen
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None