Ignite Creation Date:
2024-05-05 @ 11:56 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00182923
Status:
COMPLETED
Last Update Posted:
2008-08-29
First Post:
2005-09-12
Brief Title:
Forearm Vascular Relaxation
Sponsor:
National Institute on Aging NIA
Organization:
National Institute on Aging NIA
Study Overview
Official Title:
Determinants of Forearm Vascular Relaxation Role of Genetic Polymorphisms
Status:
COMPLETED
Status Verified Date:
2008-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to learn the effect of inherited differences on forearm blood flow responses to hormones and drugs
Detailed Description:
Differences in at least 4 genes are believed to have an important effect on responses to hormones and drugs For this study healthy volunteers of normal body weight will be screened to find xxx individuals with the genes of interest Very small doses of hormones and drugs will be given so that changes in forearm blood flow can be measured while not causing effects throughout the body A brachial artery line and venous line will be placed in the study arm so that blood samples may be withdrawn to compare amounts given into the artery and coming out of the vein after circulating through the arm Forearm blood flow is determined by the rate of swelling of the arm after a blood pressure cuff is inflated above venous and below arterial blood pressure The hormones and drugs being studied include angiotensin I angiotensin II acetylcholine sodium nitroprusside enalaprilat L-arginine phenylephrine endothelin-1 verapamil and isoproterenol This procedure will last 4-6 hours The process will be repeated with the same participant over 2 weeks later
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None