Ignite Creation Date:
2024-05-05 @ 11:57 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00187824
Status:
UNKNOWN
Last Update Posted:
2005-09-16
First Post:
2005-09-11
Brief Title:
Regulation of Endocrine Metabolic Immune and Bioenergetic Responses in Sepsis
Sponsor:
University College London Hospitals
Organization:
University College London Hospitals
Study Overview
Official Title:
Regulation of Endocrine Metabolic Immune and Bioenergetic Responses in Sepsis
Status:
UNKNOWN
Status Verified Date:
2004-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The hypothesis of this study is that bioenergetic failure in human sepsis related to endocrine metabolic and mitochondrial dysfunction is a major determinant of defective host immune responses increasing disease severity and risk of death The objectives of this study are to examine the relationship between the severity of illness and temporal changes in the activity of endocrine metabolic and bioenergetic pathways and consequent immune dysfunction in critically ill patients with sepsis and multiple organ failure in the Intensive Care Unit
Detailed Description:
The objectives of this study are to examine the relationship between the severity of illness and temporal changes in the activity of endocrine metabolic and bioenergetic pathways and consequent immune dysfunction in critically ill patients with sepsis and multiple organ failure in the Intensive Care Unit
This study will be undertaken using sequential blood sampling until ICU discharge and muscle biopsies to a maximum of 5 in critically ill patients a with or b without sepsis plus a comparator group undergoing elective orthopaedic surgery A variety of hormonal cytokine immune and mitochondrial measures wil lbe then made to assess whether any relationship exists between alterations in these different pathways and whether eventual survivors and non-survivors can be distinguished
This study will be undertaken using sequential blood sampling until ICU discharge and muscle biopsies to a maximum of 5 in critically ill patients a with or b without sepsis plus a comparator group undergoing elective orthopaedic surgery A variety of hormonal cytokine immune and mitochondrial measures wil lbe then made to assess whether any relationship exists between alterations in these different pathways and whether eventual survivors and non-survivors can be distinguished
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None