Ignite Creation Date:
2024-05-05 @ 11:57 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00188006
Status:
COMPLETED
Last Update Posted:
2005-09-16
First Post:
2005-09-09
Brief Title:
Complement Activation and Central Nervous System Injury After Coronary Artery Surgery
Sponsor:
University Hospital Angers
Organization:
University Hospital Angers
Study Overview
Official Title:
Biocompatible Cardiopulmonary Bypass and Neuropsychological Outcome After Coronary Artery Bypass Surgery
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The impact of the postoperative inflammatory response on the central nervous system after cardiac surgery is uncertain
The goal of this study was to evaluate the role of complement activation on cellular brain injury and neurological functioning in patients undergoing coronary artery surgery In addition the effect of complement activation on the cerebral vasomotricity was assessed
Because receptors to activated complement are present on astrocytes the heparin-coated cardiopulmonary bypass that reduces complement activation should minimize these postoperative neurological adverse events Heparin-coating might also influence blood flow velocity in cerebral arteries postoperatively if complement activation mediates cardiopulmonary bypass induced cerebral vasomotor dysfunction
The goal of this study was to evaluate the role of complement activation on cellular brain injury and neurological functioning in patients undergoing coronary artery surgery In addition the effect of complement activation on the cerebral vasomotricity was assessed
Because receptors to activated complement are present on astrocytes the heparin-coated cardiopulmonary bypass that reduces complement activation should minimize these postoperative neurological adverse events Heparin-coating might also influence blood flow velocity in cerebral arteries postoperatively if complement activation mediates cardiopulmonary bypass induced cerebral vasomotor dysfunction
Detailed Description:
Closed cardiopulmonary bypass and controlled suctions of pericardial shed blood were standardized in all patients
Bedside transcranial Doppler examination served to evaluate the development of cerebral vasomotor dysfunction in a subgroup of patients
Bedside transcranial Doppler examination served to evaluate the development of cerebral vasomotor dysfunction in a subgroup of patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None