Ignite Creation Date:
2024-05-05 @ 11:57 AM
Last Modification Date:
2024-10-26 @ 9:16 AM
Study NCT ID:
NCT00180752
Status:
COMPLETED
Last Update Posted:
2016-02-19
First Post:
2005-09-13
Brief Title:
HDAC Activity in Peripheral Skeletal Muscle in COPD
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
The Investigation of HDAC and NF Kappa B Activity in Peripheral Skeletal Muscle in COPD
Status:
COMPLETED
Status Verified Date:
2008-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We wish to study the effect of Chronic Obstructive Pulmonary Disease on the activity of the nuclear transcription pathway in peripheral skeletal muscle to determine whether altered activity of this pathway may be responsible for the muscle dysfunction observed in these patients
Detailed Description:
Peripheral muscle dysfunction is well recognised in COPD We wish to study patients who we have found to have weak quadriceps muscles and study the molecular mechanisms underlying this problem Patients will be well characterised with regard to their physiologic parameters and quadriceps muscle biopsies will be taken These biopsy samples will be analysed with respect to NFkappaB activity and HDAC activity by nuclear extraction and for muscle inflammatory cytokines We know that in the lung tissue of COPD patients there is evidence of a reduction in HDAC activity which might be responsible for the higher levels of pronflammatory cytokines in the lung We will also study a healthy control group and a small selection of patients who are in respiratory failure due to idiopathic scoliosis in the same way
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None