Ignite Creation Date:
2024-05-05 @ 10:18 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00007111
Status:
COMPLETED
Last Update Posted:
2015-12-23
First Post:
2000-12-07
Brief Title:
Childrens Activity and Nutrition III
Sponsor:
Augusta University
Organization:
Augusta University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To track blood pressure from childhood through adolescence
Detailed Description:
BACKGROUND
Childrens Activity and Nutrition III was originally part of the Institute-initiated Studies of Childrens Activity and Nutrition SCAN first funded in 1985 Childrens Activity and Nutrition III was renewed in 1992 as a stand-alone project with a focus on assessment of the development of hemodynamic mechanisms responsible for blood pressure BP control within the context of ethnicity and family history of early myocardial infarction MI defined as having a parent or grandparent with an MI at less than 55 years of age and a family history
Blacks have a higher mortality rate through middle adulthood than whites from coronary heart disease CHD the leading causes of death in the United States Blacks have been found to exhibit greater cardiovascular CV response to stress ie reactivity a potential risk factor for CHD as have individuals with a family history Although CHD has its pathobiologic origins in childhood little longitudinal reactivity research has been conducted in youth especially from childhood through late adolescence
DESIGN NARRATIVE
The study followed a multiethnic sample of 250 13 to 14 year olds for an additional 5 years to determine 1 whether blood pressure BP reactivity during childhood predicted changes in resting BP left ventricular mass and concentric remodeling carotid artery wall elasticity and endothelial dependent arterial dilation up to 11 years later after controlling for other expected predictors ie age gender ethnicity resting BP adiposity ambulatory BP 2 the influence of ethnicity family history and a select group of moderator variables ie environmental stress anger and John Henryism coping styles aerobic fitness on youths cardiovascular CV reactivity and 3 the stability of CV reactivity and a 24- hour ambulatory BP from childhood through late adolescence The long- term objectives were to provide a better understanding of the development of CV reactivity in youth and its influence upon early pathobiologic markers of coronary heart disease prior to overt manifestation of disease
Childrens Activity and Nutrition III was originally part of the Institute-initiated Studies of Childrens Activity and Nutrition SCAN first funded in 1985 Childrens Activity and Nutrition III was renewed in 1992 as a stand-alone project with a focus on assessment of the development of hemodynamic mechanisms responsible for blood pressure BP control within the context of ethnicity and family history of early myocardial infarction MI defined as having a parent or grandparent with an MI at less than 55 years of age and a family history
Blacks have a higher mortality rate through middle adulthood than whites from coronary heart disease CHD the leading causes of death in the United States Blacks have been found to exhibit greater cardiovascular CV response to stress ie reactivity a potential risk factor for CHD as have individuals with a family history Although CHD has its pathobiologic origins in childhood little longitudinal reactivity research has been conducted in youth especially from childhood through late adolescence
DESIGN NARRATIVE
The study followed a multiethnic sample of 250 13 to 14 year olds for an additional 5 years to determine 1 whether blood pressure BP reactivity during childhood predicted changes in resting BP left ventricular mass and concentric remodeling carotid artery wall elasticity and endothelial dependent arterial dilation up to 11 years later after controlling for other expected predictors ie age gender ethnicity resting BP adiposity ambulatory BP 2 the influence of ethnicity family history and a select group of moderator variables ie environmental stress anger and John Henryism coping styles aerobic fitness on youths cardiovascular CV reactivity and 3 the stability of CV reactivity and a 24- hour ambulatory BP from childhood through late adolescence The long- term objectives were to provide a better understanding of the development of CV reactivity in youth and its influence upon early pathobiologic markers of coronary heart disease prior to overt manifestation of disease
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL035073 | NIH | None | httpsreporternihgovquickSearchR01HL035073 |