Ignite Creation Date:
2024-05-05 @ 10:18 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001246
Status:
RECRUITING
Last Update Posted:
2024-07-12
First Post:
1999-11-03
Brief Title:
Brain Imaging of Childhood Onset Psychiatric Disorders Endocrine Disorders and Healthy Volunteers
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Brain Imaging of Childhood Onset Psychiatric Disorders Endocrine Disorders and Healthy Volunteers
Status:
RECRUITING
Status Verified Date:
2024-05-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Magnetic Resonance Imaging MRI unlike X-rays and CT-scans does not use radiation to create a picture MRI use as the name implies magnetism to create pictures with excellent anatomical resolution Functional MRIs are diagnostic tests that allow doctors to not only view anatomy but physiology and function It is for these reasons that MRIs are excellent methods for studying the brain
In this study researchers will use MRI to assess brain anatomy and function in X and Y chromosome variation healthy volunteers and patients with a variety of childhood onset psychiatric disorders The disorders include attention deficit disorder autism congenital adrenal hyperplasia childhood-onset schizophrenia dyslexia obsessive compulsive disorder Sydenhams chorea and Tourettes syndrome
Results of the MRIs showing the anatomy of the brain and brain function will be compared across age sex gender and diagnostic groups Correlations between brain and behavioral measures will be examined for normal and clinical populations
In this study researchers will use MRI to assess brain anatomy and function in X and Y chromosome variation healthy volunteers and patients with a variety of childhood onset psychiatric disorders The disorders include attention deficit disorder autism congenital adrenal hyperplasia childhood-onset schizophrenia dyslexia obsessive compulsive disorder Sydenhams chorea and Tourettes syndrome
Results of the MRIs showing the anatomy of the brain and brain function will be compared across age sex gender and diagnostic groups Correlations between brain and behavioral measures will be examined for normal and clinical populations
Detailed Description:
Objective Our work is driven by the core hypotheses that many of the most severe neuropsychiatric disorders of childhood onset are associated with deviations from the path of normal brain development the neuroanatomical substrates of which can be detected by magnetic resonance imaging Consequently the long-term goals of the protocol are to 1 map neuroanatomic and neurophysiological trajectories of brain development in health and illness and 2 discern influences on those trajectories from demographic eg age and sex cognitivebehavioral eg IQ and clinical eg presenceabsence of a known neurogenetic disorders factors Data from the project have resulted in seminal papers on Attention-DeficitHyperactivity Disorder Childhood-Onset Schizophrenia and typical pediatric brain development The biological bases of male female differences are explored via studies of subjects with anomalous sex chromosome numbers eg XO XXX XYY XXYY XXXXY
Study population Our studies include data from typically developing youth and individuals with a range of psychiatric presentations from behaviorally-defined eg Childhood-Onset Schizophrenia Autism Spectrum Disorder as well as genetically-defined eg Sex Chromosome Aneuploidy groups Participants span a wide age range from 3 years of age upwards
Design The study design is to have participants come to the NIH for brain imaging psychologicalpsychiatric testing and genetic characterization Assessment visits each take approximately 2 days to complete Participants are invited to return for longitudinal assessments at approximately 2-year intervals
Outcome Measures Primary outcome measure used to date have derived from T1-weighted structural neuroimaging data which enable us to characterize how a range of anatomical brain phenotypes vary as a function of age sex behavioralcognitive traits diagnostic status and genotype Analyses also consider how these factors relate to other outcomes of interest including gene expression levels functional metrics from in vivo neuroimaging and questionnaireinterview-based assessment of clinical features
Study population Our studies include data from typically developing youth and individuals with a range of psychiatric presentations from behaviorally-defined eg Childhood-Onset Schizophrenia Autism Spectrum Disorder as well as genetically-defined eg Sex Chromosome Aneuploidy groups Participants span a wide age range from 3 years of age upwards
Design The study design is to have participants come to the NIH for brain imaging psychologicalpsychiatric testing and genetic characterization Assessment visits each take approximately 2 days to complete Participants are invited to return for longitudinal assessments at approximately 2-year intervals
Outcome Measures Primary outcome measure used to date have derived from T1-weighted structural neuroimaging data which enable us to characterize how a range of anatomical brain phenotypes vary as a function of age sex behavioralcognitive traits diagnostic status and genotype Analyses also consider how these factors relate to other outcomes of interest including gene expression levels functional metrics from in vivo neuroimaging and questionnaireinterview-based assessment of clinical features
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 89-M-0006 | None | None | None |