Ignite Creation Date:
2024-05-05 @ 10:18 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001753
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Study of the Effects of Temperature on Metabolism in Human Muscle
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Study of Temperature Effects on Skeletal Muscle Aerobic Energy Metabolism
Status:
COMPLETED
Status Verified Date:
1999-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the role of temperature in changing energy metabolism in human muscle In order to do this researchers will use magnetic resonance imaging MRI to provide information about how parts of muscle operate during exercise
Magnetic resonance imaging MRI is a diagnostic tool that creates high quality images of the human body without the use of X-ray radiation In this study MRI will be used to measure the temperature and energy level of specific muscles during rest and exercise In addition the muscles being tested will be heated and cooled to see if temperature directly affects levels of energy in muscle
Magnetic resonance imaging MRI is a diagnostic tool that creates high quality images of the human body without the use of X-ray radiation In this study MRI will be used to measure the temperature and energy level of specific muscles during rest and exercise In addition the muscles being tested will be heated and cooled to see if temperature directly affects levels of energy in muscle
Detailed Description:
This study will examine the role of temperature in modulating aspects of energy metabolism in human skeletal muscle Tests will be conducted at rest and during concentric dorsiflexion exercise of the Tibialis anterior TA muscle using an existing custom-designed dynamometer in conjunction with mild local heating and cooling Magnetic resonance spectroscopy MRS performed in a 4-tesla whole-body NMR system will be used to non-invasively measure muscle temperature and energy-state Specifically these tests will assess the extent to which temperature changes occur during aerobic exercise and how small temperature changes affect mitochondrial function in-vivo
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-H-0166 | None | None | None |