Ignite Creation Date:
2024-05-05 @ 11:58 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00190177
Status:
COMPLETED
Last Update Posted:
2013-10-18
First Post:
2005-09-12
Brief Title:
ECLAXIRSearch for an Association Between CX3CR1 V249I Polymorphism Preeclampsia and Endothelial Injury
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study hypothesis is the involvement of the couple CX3CR1CX3CL1 in occurrence of endothelial injury in preeclampsia According to this hypothesis Carriers of the I249 allele who express less CX3CR1 shoud be protected against this risk The main objective of the study is the search of an association between CX3CR1 V249I polymorphism and preeclampsia The secondary aims are the search of an association with the most severe forms of preeclampsia and endothelial injury
Detailed Description:
It is a case-control multicenter study 185 caucasian pregnant women with preeclampsia and 185 paired controls without preeclampsia will be included
The frequency of the V249I polymorphism in african black population will be determined by studying 200 subjects 100 cases and 100 controls
The V249I polymorphism will be identified by PCR followed by enzyme digestion Endothelial injury will be identified using three assays von Willebrand factor soluble VCAM-1 and thrombomodulin plasma levels
CX3CR1 involvement in preeclampsia would have potential diagnostic and therapeutic consequences
The frequency of the V249I polymorphism in african black population will be determined by studying 200 subjects 100 cases and 100 controls
The V249I polymorphism will be identified by PCR followed by enzyme digestion Endothelial injury will be identified using three assays von Willebrand factor soluble VCAM-1 and thrombomodulin plasma levels
CX3CR1 involvement in preeclampsia would have potential diagnostic and therapeutic consequences
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None