Ignite Creation Date:
2024-05-05 @ 11:58 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00199459
Status:
COMPLETED
Last Update Posted:
2009-09-03
First Post:
2005-09-12
Brief Title:
Proteomic Study of Urinary Stone Disease
Sponsor:
Lawson Health Research Institute
Organization:
Lawson Health Research Institute
Study Overview
Official Title:
Urinary Proteomic Profiling Using ProteinChip SELDI-TOF-MS A Potential Means of Identifying Protein Biomarkers of Urinary Stone Formers
Status:
COMPLETED
Status Verified Date:
2009-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Urinary protein levels are not routinely measured in stone patients while there is strong evidence that proteins play a role in the etiology of stones The purpose of this study is to examine the urinary and serum proteins of stone formers compared to healthy subjects utilizing the high throughput method Surface Enhanced Laser DesorptionIonization SELDI We hypothesize that there is a unique set of proteins expressed in serum and urine in stone patients that can be detected by SELDI Ultimately this will better our understanding of stone disease and help develop new prevention strategies
Detailed Description:
Urinary stone disease affects 10 of the Canadian population during their lifetime and approximately half of these patients will have another episode within ten years Currently patients undergo metabolic testing serum and 24 hour urine tests to identify modifiable risk factors however no modifiable risk factors are identified in many patients yet they continue to form stones New techniques must be developed to identify stone patients at risk for future recurrences and ultimately to develop more specific prevention strategies
Urinary protein levels are not routinely measured in stone patients while there is strong evidence that proteins play a role in the etiology of stones The purpose of this study is to examine the urinary and serum proteins of stone formers compared to healthy subjects utilizing the high throughput method Surface Enhanced Laser DesorptionIonization SELDI We hypothesize that there is a unique set of proteins expressed in serum and urine in stone patients that can be detected by SELDI Once a protein is identified as a biomarker a specific assay similar to a quick and affordable dipstick test may be developed to identify those stone patients at risk of future stones Ultimately this will better our understanding of stone disease and help develop new prevention strategies
Comparisons protein profiles serumurine of stone patients both during the presence of a stone and 6 weeks after they have passed it comparison of stone profiles of stone patients with controls non-forming stone patients
Urinary protein levels are not routinely measured in stone patients while there is strong evidence that proteins play a role in the etiology of stones The purpose of this study is to examine the urinary and serum proteins of stone formers compared to healthy subjects utilizing the high throughput method Surface Enhanced Laser DesorptionIonization SELDI We hypothesize that there is a unique set of proteins expressed in serum and urine in stone patients that can be detected by SELDI Once a protein is identified as a biomarker a specific assay similar to a quick and affordable dipstick test may be developed to identify those stone patients at risk of future stones Ultimately this will better our understanding of stone disease and help develop new prevention strategies
Comparisons protein profiles serumurine of stone patients both during the presence of a stone and 6 weeks after they have passed it comparison of stone profiles of stone patients with controls non-forming stone patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| PSI 04-041 | None | None | None |