Ignite Creation Date:
2024-05-05 @ 11:58 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00199732
Status:
COMPLETED
Last Update Posted:
2013-04-17
First Post:
2005-09-14
Brief Title:
Evaluation of cccDNA and Total HBV DNA Kinetics in Lymphocytes Total Blood and Serum in Chronic Hepatitis B Patients Treated With Adefovir Dipivoxil and Peg Interferon Alpha 2a
Sponsor:
University Hospital Limoges
Organization:
University Hospital Limoges
Study Overview
Official Title:
Evaluation of cccDNA and Total HBV DNA Kinetics in Lymphocytes Total Blood and Serum in Chronic Hepatitis B Patients Treated With Adefovir Dipivoxil and Peg Interferon Alpha 2a
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DNA-EVAL
Brief Summary:
Serum HBV DNA is a referent but insufficient marker of therapeutic follow-up in chronic hepatitis B treatment Intra hepatic cccDNA disappearance reflects HBV eradication in the liver
Intra lymphocyte cccDNA could be a new marker of HBV eradication after treatment
The major interest of this marker is that it can be measured by a simple blood test instead of a liver biopsy
Intra lymphocyte cccDNA could be a new marker of HBV eradication after treatment
The major interest of this marker is that it can be measured by a simple blood test instead of a liver biopsy
Detailed Description:
- Studying intra lymphocyte and blood cccDNA before inclusions D0 then each month during the first three months each three months during treatment and follow-up
- Viral kineticsBefore inclusions at D0 then monthly till the end of treatment and follow-up Evolution of quantitative viraemia in serum Evolution of quantitative viraemia in circulating lymphocytes Evolution of quantitative viraemia in total blood
- Studying viral genotypes
- Viral kineticsBefore inclusions at D0 then monthly till the end of treatment and follow-up Evolution of quantitative viraemia in serum Evolution of quantitative viraemia in circulating lymphocytes Evolution of quantitative viraemia in total blood
- Studying viral genotypes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None