Ignite Creation Date:
2024-05-05 @ 11:58 AM
Last Modification Date:
2024-10-26 @ 9:17 AM
Study NCT ID:
NCT00197366
Status:
TERMINATED
Last Update Posted:
2017-11-28
First Post:
2005-09-14
Brief Title:
Development of Resistance Mutations in Pregnant HIV-positive Women Following Perinatal Antiretroviral Therapy in Israel
Sponsor:
Hadassah Medical Organization
Organization:
Hadassah Medical Organization
Study Overview
Official Title:
Development of Resistance Mutations in the Human Immunodeficiency Virus HIV in Pregnant HIV Women Receiving Perinatal Antiretroviral Therapy in Israel
Status:
TERMINATED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Difficulties in data collection
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
It has been shown that treatment of HIV-positive women with antiretroviral medication during pregnancy reduces the risk of HIV transmission to the child However such treatment could lead to the selection of resistant virus strains in the mother The object of this study is to check HIV pregnant women for resistance mutations in HIV before and after the antiretroviral therapy they receive during pregnancy HIV-positive newborns will also be tested to see if a resistant virus strain was transmitted from mother to child
Detailed Description:
The project will be performed in collaboration with the Israeli National HIV Reference Center Laboratory which maintains a national bank of HIV-positive blood samples and with HIVAIDS treatment centers located throughout Israel
An initial survey will identify retrospectively those HIV women who were given antiretroviral therapy while pregnant and stopped treatment after delivery The list of HIV deliveries over the past five years in each participating hospital will be reviewed and all HIV-positive women who received antiretroviral treatment during pregnancy will be invited to participate in the study project Women who are currently pregnant or become pregnant during the study will be invited to participate when pregnancy is diagnosed After obtaining informed consent two blood samples will be obtained one before the initiation of perinatal treatment and the other following delivery Due to technical limitations only samples with viral loads above 1000 cpml can be genotyped It is expected that HIV loads will rise following cessation of antiretroviral treatment and that almost all samples will be eligible for resistance testing
In addition after obtaining maternal informed consent samples from newborns infected perinatally with HIV will also be tested for resistance mutations and these will be compared with the resistance pattern found in the mother
The samples obtained will be tested for genotypic resistance mutations The results will be transmitted to the treating physician to assist in choice of antiretroviral therapy for the women and their children if needed The data will also be used to establish a national database to evaluate and improve existing protocols for perinatal antiretroviral treatment and will be used to contribute to international databases of HIV resistance All resistance data except that given to the health care providers will be transmitted without additional identifying information
An initial survey will identify retrospectively those HIV women who were given antiretroviral therapy while pregnant and stopped treatment after delivery The list of HIV deliveries over the past five years in each participating hospital will be reviewed and all HIV-positive women who received antiretroviral treatment during pregnancy will be invited to participate in the study project Women who are currently pregnant or become pregnant during the study will be invited to participate when pregnancy is diagnosed After obtaining informed consent two blood samples will be obtained one before the initiation of perinatal treatment and the other following delivery Due to technical limitations only samples with viral loads above 1000 cpml can be genotyped It is expected that HIV loads will rise following cessation of antiretroviral treatment and that almost all samples will be eligible for resistance testing
In addition after obtaining maternal informed consent samples from newborns infected perinatally with HIV will also be tested for resistance mutations and these will be compared with the resistance pattern found in the mother
The samples obtained will be tested for genotypic resistance mutations The results will be transmitted to the treating physician to assist in choice of antiretroviral therapy for the women and their children if needed The data will also be used to establish a national database to evaluate and improve existing protocols for perinatal antiretroviral treatment and will be used to contribute to international databases of HIV resistance All resistance data except that given to the health care providers will be transmitted without additional identifying information
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None