Ignite Creation Date:
2024-05-05 @ 10:22 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005252
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Physicians Health Study Study of Low Cardiovascular Disease Mortality
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To explain the extremely low cardiovascular mortality among Physicians Health Study PHS participants by ascertaining all cardiovascular and total deaths among the 90457 physicians who returned enrollment forms but were not randomized into the study Also to compare the mortality experience of randomized physicians with various subgroups of non-participants
Detailed Description:
BACKGROUND
The Physicians Health Study was a randomized double-blind placebo-controlled primary prevention trial designed to test whether 325 mg aspirin every other day reduced the risk of cardiovascular disease and whether 50 mg beta-carotene on alternate days decreased cancer incidence among 22071 male physicians aged 40-84 years in 1982 On December 18 1987 the external Data Monitoring Board recommended early termination of the blinded aspirin component of the trial based on the emergence of a statistically extreme benefit of aspirin on both fatal and nonfatal myocardial infarction as well as the extraordinarily low cardiovascular mortality rates among study participants
DESIGN NARRATIVE
In January 1982 the Physicians Health Study investigators purchased a tape from the American Medical Association that contained the names of all male physicians born between January 1 1907 and December 31 1942 The tape provided the basis for the invitation to join the trial A new computer tape was purchased from the AMA that contained names addresses and dates of birth for all physicians registered as of December 1982 current and 1982 addresses and any reported deaths This tape was matched against Physician Health Study data files to eliminate those not on the original tape as well as those known to be deceased at the time of the original mailing When the match was complete the results were a new tape that included names most recent addresses and dates of birth of all those who were invited to participate in the trial A new master study tape was compiled that included all non-randomized potentially eligible respondents to the invitational mailing as well as a 35 percent random sample of the non-respondents This group of 138460 comprised the cohort The National Death Index NDI was searched from January 1 1982 to January 25 1988 the official termination date of the trial for each physician in the cohort as well as for the 22071 randomized participants A copy of the death certificate was obtained from the state department of vital statistics for each death identified by the NDI in order to distinguish between vascular and non-vascular deaths An Endpoints Committee using death certificates and medical records in some cases assigned the cause of death to be entered into the data base
Analyses were performed comparing all randomized versus all non-randomized respondents those randomized versus those eligible but unwilling to participate those randomized versus those initially willing and eligible who enrolled in an 18 week period but were excluded prior to randomization Baseline data on the enrollment forms were examined to determine whether differences in mortality rates could be explained by differences in cardiovascular risk factors among the groups
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The Physicians Health Study was a randomized double-blind placebo-controlled primary prevention trial designed to test whether 325 mg aspirin every other day reduced the risk of cardiovascular disease and whether 50 mg beta-carotene on alternate days decreased cancer incidence among 22071 male physicians aged 40-84 years in 1982 On December 18 1987 the external Data Monitoring Board recommended early termination of the blinded aspirin component of the trial based on the emergence of a statistically extreme benefit of aspirin on both fatal and nonfatal myocardial infarction as well as the extraordinarily low cardiovascular mortality rates among study participants
DESIGN NARRATIVE
In January 1982 the Physicians Health Study investigators purchased a tape from the American Medical Association that contained the names of all male physicians born between January 1 1907 and December 31 1942 The tape provided the basis for the invitation to join the trial A new computer tape was purchased from the AMA that contained names addresses and dates of birth for all physicians registered as of December 1982 current and 1982 addresses and any reported deaths This tape was matched against Physician Health Study data files to eliminate those not on the original tape as well as those known to be deceased at the time of the original mailing When the match was complete the results were a new tape that included names most recent addresses and dates of birth of all those who were invited to participate in the trial A new master study tape was compiled that included all non-randomized potentially eligible respondents to the invitational mailing as well as a 35 percent random sample of the non-respondents This group of 138460 comprised the cohort The National Death Index NDI was searched from January 1 1982 to January 25 1988 the official termination date of the trial for each physician in the cohort as well as for the 22071 randomized participants A copy of the death certificate was obtained from the state department of vital statistics for each death identified by the NDI in order to distinguish between vascular and non-vascular deaths An Endpoints Committee using death certificates and medical records in some cases assigned the cause of death to be entered into the data base
Analyses were performed comparing all randomized versus all non-randomized respondents those randomized versus those eligible but unwilling to participate those randomized versus those initially willing and eligible who enrolled in an 18 week period but were excluded prior to randomization Baseline data on the enrollment forms were examined to determine whether differences in mortality rates could be explained by differences in cardiovascular risk factors among the groups
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL042441 | NIH | None | httpsreporternihgovquickSearchR01HL042441 |