Ignite Creation Date:
2024-05-05 @ 11:59 AM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00204178
Status:
UNKNOWN
Last Update Posted:
2005-12-01
First Post:
2005-09-13
Brief Title:
The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney
Sponsor:
Uniwersytet Mikolaja Kopernika w Toruniu
Organization:
Uniwersytet Mikolaja Kopernika w Toruniu
Study Overview
Official Title:
The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney
Status:
UNKNOWN
Status Verified Date:
2005-08
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Measurement of reactive oxygen species production and antioxidant system status before and directly after reperfusion of the transplanted kidney and influence of oxidant stress on kidney function in 2 and 6 weeks
Detailed Description:
Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ In kidney transplant recipients following factors were measured glutathione level activities of glutathione peroxidase GSH-PX catalase CAT and superoxide dismutase SOD and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan
Blood was sampled from peripheral vein before reperfusion and directly from renal vein 5 and 15 minutes after reperfusion
Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation
Blood was sampled from peripheral vein before reperfusion and directly from renal vein 5 and 15 minutes after reperfusion
Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None