Ignite Creation Date:
2024-05-05 @ 11:59 AM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00202072
Status:
UNKNOWN
Last Update Posted:
2005-09-20
First Post:
2005-09-12
Brief Title:
Mucin in Sputum of CF During Pulmonary Exacerbation
Sponsor:
Philipps University Marburg Medical Center
Organization:
Philipps University Marburg Medical Center
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2005-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether mucin is increased during pulmonay exacerbations in adult patients with cystic fibrosis CF
Detailed Description:
CF is typically associated with mucus hypersecretion in the airways In health mucin is the major macromolecular component and is responsible for the protective and clearance properties of the mucus gel In a recent study we found that mucins are decreased in the sputum of adult CF patients
In this study we want to investigate the differences on the mucin and DNA quantity and quality of airway secretions in during pulmoanry exacerbationWe hypothesize that during an exacerbation the mucin and DNA amount is increasing
The aim of this study is to evaluate the molecular mucins and structure properties mucin-DNA-network of the airway secretions in CF related to the severity of the disease
We characterize sputum composition of patients with pulmonary exacerbations Using gel electrophoresis and dot-blot with specific antibodies we will analyze MUC5AC and MUC5B mucins DNA amount will be measured by microfluorimetry With the laser scanning confocal microscopy the mucin-DNA-network will be evaluated
The significance of these studies is that they will give us novel information about the pathogenesis of chronic inflammatory airway diseases provide tools for assessing the progression of lung disease and most critically will identify novel opportunities and targets for therapeutic intervention
In this study we want to investigate the differences on the mucin and DNA quantity and quality of airway secretions in during pulmoanry exacerbationWe hypothesize that during an exacerbation the mucin and DNA amount is increasing
The aim of this study is to evaluate the molecular mucins and structure properties mucin-DNA-network of the airway secretions in CF related to the severity of the disease
We characterize sputum composition of patients with pulmonary exacerbations Using gel electrophoresis and dot-blot with specific antibodies we will analyze MUC5AC and MUC5B mucins DNA amount will be measured by microfluorimetry With the laser scanning confocal microscopy the mucin-DNA-network will be evaluated
The significance of these studies is that they will give us novel information about the pathogenesis of chronic inflammatory airway diseases provide tools for assessing the progression of lung disease and most critically will identify novel opportunities and targets for therapeutic intervention
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None