Ignite Creation Date:
2024-05-05 @ 12:00 PM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00205686
Status:
COMPLETED
Last Update Posted:
2006-01-06
First Post:
2005-09-13
Brief Title:
Effects of DHEA and Exercise in the Elderly
Sponsor:
Washington University School of Medicine
Organization:
Washington University School of Medicine
Study Overview
Official Title:
DHEAExercise-Effect on Sarcopenia and Osteopenia of Aging
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
DHEA or dehydroepiandrosterone is a naturally occurring hormone secreted by tghe adrenal galnds The secretion of HDEA declines with aging DHEA is considered a food supplement and it is not regulated by the FDA The purpose of this research is to evaluate ceratin of the biological effects of a reaplcement dose of DHEA As you get older DHEA levels are lower than you were younger The replamcent dose is the dose of DHEA that will raise DHEA levesl to the levels found in young people Anotehr purpose is to determine whether DHEA enhances the adaptations to an exercise training program
Detailed Description:
DHEA declines dramatically with age Low DHEA levels have been found to correlate with sarcopenia and osteopenia It is therefore postulated that many physiologic changes of aging are secondary to the decline in DHEA Thus the objective of the proposed research is to evaluate the effect of DHEA replacement on age-related changes in body composition muscle function and metabolism and bone mass in healthy older adults The specific aims are to evaluate the effects of DHEA replacement 50 mgd alone or in combination with resistance exercise training on a lean body mass intraabdominal fat and thigh muscle volume and muscle protein synthesis rate b bone mineral density BMD of the total body lumbar spine and hip and biochemical markers of bone turnover and c insulin sensitivity It is hypothesized that DHEA administration will have additive or synergistic effects with exercise Healthy but sedentary subjects aged 65-78 years old will be randomized to receive either DHEA 50 mgd or placebo and to participate in either supervised or home exercise training programs The supervised exercise program will consist of resistance training designed to increase muscle mass strength and bone mass and decrease fat mass The goal of this research is to provide information on the potential role of DHEA replacement therapy in maintaining the physical health and functional capacity of older people
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| K23RR016191 | NIH | None | httpsreporternihgovquickSearchK23RR016191 |