Ignite Creation Date:
2024-05-05 @ 12:00 PM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00209144
Status:
COMPLETED
Last Update Posted:
2014-06-16
First Post:
2005-09-14
Brief Title:
Phase 1 Study of Potential Anti-Inflammatory Effects of Glucose Control During Acute Myocardial Infarction
Sponsor:
Emory University
Organization:
Emory University
Study Overview
Official Title:
Effects of Intense Glycemic Control on Markers of Inflammation and Thrombosis in Patients Treated With Percutaneous Coronary Intervention for Acute Myocardial Infarction
Status:
COMPLETED
Status Verified Date:
2014-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine if intense control of high glucose levels in patients treated with angioplasty for heart attack has anti-inflammatory and anti-thrombotic effects
Detailed Description:
Two out of three heart attack patients have high blood sugar Half of these patients have diabetes and the other half have what is called pre-diabetes meaning that they have higher blood sugar than normal but not high enough to have diabetes Over 40 million Americans have pre-diabetes
For more than 70 years doctors have known that patients with high blood sugar do not survive or recover from heart attacks as well as patients with normal blood sugar Doctors have not figured out the reason for this difference
The best treatment available for heart attacks is called angioplasty Angioplasty means that doctors put a small balloon into a blocked blood vessel blow up the balloon to open the blockage and then insert a small wire tube called a stent to hold the blockage open Blood thinners and other heart medicines are also given to these patients to help blood get through the blocked blood vessel Angioplasty and these medicines have helped many people survive and recover from heart attacks But even when doctors use these drugs balloons and stents patients who have high blood sugar still do worse than patients with normal blood sugar
We want to figure out why high blood sugar is bad for patients with heart attacks Past research tells us there might be two reasons The first is that high blood sugar increases inflammation which is part of the bodys natural response to heart attack Inflammation is what causes a persons skin to turn hot and red after it is injured Although inflammation is part of the bodys natural healing process too much inflammation can be harmful We think that patients with high blood sugar during heart attacks have too much inflammation The second reason why high blood sugar might be bad for heart attack patients is that high blood sugar makes blood thicker When a blood vessel is blocked thick blood makes it harder for the heart to get the blood flow it needs This is why doctors use aspirin and other blood thinners when they treat patients with heart attacks
The amount of inflammation and thickness in a persons blood can be measured in a laboratory In this study we want to measure the amount of inflammation and thickness in patients blood to see if there is a difference between patients with normal blood sugar patients with pre-diabetes and patients with diabetes If we can show that there is a difference this will help us to understand why high blood sugar is bad for patients with heart attacks
We also want to see if lowering a patients high blood sugar is helpful during a heart attack The standard therapy for lowering blood sugar in diabetic patients with heart attacks is to check their blood sugar four times each day while they are in the hospital and to give them a shot of a medicine called insulin that helps bring the blood sugar level down if it is high However research tells us that this way of treating diabetic patients doesnt get their blood sugar low enough Also patients with pre-diabetes and patients who have diabetes but dont know it usually dont get any insulin so their sugar levels are usually allowed to run high while they are in the hospital In this study we will treat half of diabetic and pre-diabetic patients the usual way and give the other half insulin through an IV for the first 24 hours that they are in the hospital If we compare the inflammation and blood thickness between patients treated the usual way and patients treated with more insulin we can figure out if lowering blood sugar more than usual is helpful to patients with heart attack
If we can find out why high blood sugar is harmful to patients with heart attacks and if we can show that treating these patients with more insulin than usual lessens these harmful effects then we will be able to improve the way that these patients are treated This could result in better survival and recovery for many heart attack patients
All patients who volunteer for this study will get the best treatment available for heart attack- angioplasty blood thinners and the other heart medications that are usually given to these patients Patients who have high blood sugar will be divided into two groups One group will have their blood sugars measured and treated in the usual way The other group will be treated with insulin run through an IV for 24 hours After 24 hours all patients will be treated in the usual way
About one tablespoon of blood will be drawn from each patient at the time they sign up for the study and then 6 12 24 and 48 hours later This blood will be used to test for inflammation and blood thickness
The only ways in which patients who volunteer for this study will be treated differently from the standard of care are that they might receive more insulin than usual and they will have more blood drawn than usual Giving extra insulin to these patients should not cause them harm and may even help them Since only about 5 tablespoons of extra blood will be drawn from each patient this should not cause patients any harm
Goals of this study
1 To see what happens to blood inflammation and thickness in heart attack patients with normal blood sugar and compare this to patients with high blood sugar
2 To find out lowering patients blood sugar levels more than we currently do will result in less blood inflammation and thickness
For more than 70 years doctors have known that patients with high blood sugar do not survive or recover from heart attacks as well as patients with normal blood sugar Doctors have not figured out the reason for this difference
The best treatment available for heart attacks is called angioplasty Angioplasty means that doctors put a small balloon into a blocked blood vessel blow up the balloon to open the blockage and then insert a small wire tube called a stent to hold the blockage open Blood thinners and other heart medicines are also given to these patients to help blood get through the blocked blood vessel Angioplasty and these medicines have helped many people survive and recover from heart attacks But even when doctors use these drugs balloons and stents patients who have high blood sugar still do worse than patients with normal blood sugar
We want to figure out why high blood sugar is bad for patients with heart attacks Past research tells us there might be two reasons The first is that high blood sugar increases inflammation which is part of the bodys natural response to heart attack Inflammation is what causes a persons skin to turn hot and red after it is injured Although inflammation is part of the bodys natural healing process too much inflammation can be harmful We think that patients with high blood sugar during heart attacks have too much inflammation The second reason why high blood sugar might be bad for heart attack patients is that high blood sugar makes blood thicker When a blood vessel is blocked thick blood makes it harder for the heart to get the blood flow it needs This is why doctors use aspirin and other blood thinners when they treat patients with heart attacks
The amount of inflammation and thickness in a persons blood can be measured in a laboratory In this study we want to measure the amount of inflammation and thickness in patients blood to see if there is a difference between patients with normal blood sugar patients with pre-diabetes and patients with diabetes If we can show that there is a difference this will help us to understand why high blood sugar is bad for patients with heart attacks
We also want to see if lowering a patients high blood sugar is helpful during a heart attack The standard therapy for lowering blood sugar in diabetic patients with heart attacks is to check their blood sugar four times each day while they are in the hospital and to give them a shot of a medicine called insulin that helps bring the blood sugar level down if it is high However research tells us that this way of treating diabetic patients doesnt get their blood sugar low enough Also patients with pre-diabetes and patients who have diabetes but dont know it usually dont get any insulin so their sugar levels are usually allowed to run high while they are in the hospital In this study we will treat half of diabetic and pre-diabetic patients the usual way and give the other half insulin through an IV for the first 24 hours that they are in the hospital If we compare the inflammation and blood thickness between patients treated the usual way and patients treated with more insulin we can figure out if lowering blood sugar more than usual is helpful to patients with heart attack
If we can find out why high blood sugar is harmful to patients with heart attacks and if we can show that treating these patients with more insulin than usual lessens these harmful effects then we will be able to improve the way that these patients are treated This could result in better survival and recovery for many heart attack patients
All patients who volunteer for this study will get the best treatment available for heart attack- angioplasty blood thinners and the other heart medications that are usually given to these patients Patients who have high blood sugar will be divided into two groups One group will have their blood sugars measured and treated in the usual way The other group will be treated with insulin run through an IV for 24 hours After 24 hours all patients will be treated in the usual way
About one tablespoon of blood will be drawn from each patient at the time they sign up for the study and then 6 12 24 and 48 hours later This blood will be used to test for inflammation and blood thickness
The only ways in which patients who volunteer for this study will be treated differently from the standard of care are that they might receive more insulin than usual and they will have more blood drawn than usual Giving extra insulin to these patients should not cause them harm and may even help them Since only about 5 tablespoons of extra blood will be drawn from each patient this should not cause patients any harm
Goals of this study
1 To see what happens to blood inflammation and thickness in heart attack patients with normal blood sugar and compare this to patients with high blood sugar
2 To find out lowering patients blood sugar levels more than we currently do will result in less blood inflammation and thickness
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 6-56553 | None | None | None |