Ignite Creation Date:
2024-05-05 @ 12:00 PM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00209105
Status:
COMPLETED
Last Update Posted:
2013-11-13
First Post:
2005-09-13
Brief Title:
Characterizing Psychological Consequences of Childhood Trauma
Sponsor:
Emory University
Organization:
Emory University
Study Overview
Official Title:
Emory Conte Center for the Neuroscience of Mental Disorders Psychobiology of Childhood Trauma
Status:
COMPLETED
Status Verified Date:
2013-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will characterize the mental health consequences of early-life trauma
Detailed Description:
This primary goal of this Center is to characterize the neurobiological consequences of early-life trauma The Center comprises 6 projects that include human subjects Human subjects are recruited through Project 6
Project 2 Psychoimmunology PI AH Miller Project 4 A Model of Learned SafetyPI M Davis Project 6 Clinical PsychobiologyPI C Heim Project 7 Children of Depressed MothersPI Z Stowe Project 8 Functional Brain Imaging PIs HS Mayberg G Berns Project 9 Structural Anatomical Connectivity Studies PI CKilts X Hu
Project 2 The study seeks to examine the impact of psychosocial stress on neuroendocrine and immune signaling pathways of adult men and women with and without major depression who have experienced serious trauma abuse loss during development Serial blood samples will be collected at baseline and after an acute speechmath stressor see Project 6 Assessments include IL-1alpha and beta IL-6 TNF alpha as well as DNS binding of relevant neuroendocrine-immune transcription factors ie GR CREB and NFkB
Project 4 This study uses a model of that allows for the independent evaluation of excitation and inhibition of fear-conditioning measured with the acoustic startle reflex In addition a dark-enhanced startle paradigm will be used that tests for anxiety The effects of early-life stress will be evaluated in humans with and without major depressive disorder
Project 6 This study assesses neuroendocrine and autonomic responses to stress and pharmacological challenge in subjects with and without major depression who have or have nor experienced early life stress We seek to identify causes of variability in neuroendocrine-autonomic outcome after early life stress To achieve this principle aim we study the role of moderating and mediating factors including gender genotype typetiming of childhood trauma as well as the role of adulthood trauma comorbidity and cognitive dysfunction The projects serves as a human subjects core for the other projects
Project 7 This project characterizes effects of maternal depression on offspring in a longitudinal study Women with and without depression will be prospectively followed through pregnancy and the first 6 months post-partum Maternal stress and psychopathology pregnancy and birth complications medications and infants physiological and behavioral stress responses will be assessed
Project 8 This study uses PET and fMRI to characterize the impact of early-life stress on functional neural pathways mediating mood reactivity self reference and reward-processing in patients with major depression Cortical-limbic-striatal changes in cases with early stress but no psychopathology that define vulnerability to depression are also identified
Project 9 This Project uses data obtained in Project 8 as well as diffusion tensor imaging to define the influence of early-life trauma on brain anatomical and functional connectivity
Project 2 Psychoimmunology PI AH Miller Project 4 A Model of Learned SafetyPI M Davis Project 6 Clinical PsychobiologyPI C Heim Project 7 Children of Depressed MothersPI Z Stowe Project 8 Functional Brain Imaging PIs HS Mayberg G Berns Project 9 Structural Anatomical Connectivity Studies PI CKilts X Hu
Project 2 The study seeks to examine the impact of psychosocial stress on neuroendocrine and immune signaling pathways of adult men and women with and without major depression who have experienced serious trauma abuse loss during development Serial blood samples will be collected at baseline and after an acute speechmath stressor see Project 6 Assessments include IL-1alpha and beta IL-6 TNF alpha as well as DNS binding of relevant neuroendocrine-immune transcription factors ie GR CREB and NFkB
Project 4 This study uses a model of that allows for the independent evaluation of excitation and inhibition of fear-conditioning measured with the acoustic startle reflex In addition a dark-enhanced startle paradigm will be used that tests for anxiety The effects of early-life stress will be evaluated in humans with and without major depressive disorder
Project 6 This study assesses neuroendocrine and autonomic responses to stress and pharmacological challenge in subjects with and without major depression who have or have nor experienced early life stress We seek to identify causes of variability in neuroendocrine-autonomic outcome after early life stress To achieve this principle aim we study the role of moderating and mediating factors including gender genotype typetiming of childhood trauma as well as the role of adulthood trauma comorbidity and cognitive dysfunction The projects serves as a human subjects core for the other projects
Project 7 This project characterizes effects of maternal depression on offspring in a longitudinal study Women with and without depression will be prospectively followed through pregnancy and the first 6 months post-partum Maternal stress and psychopathology pregnancy and birth complications medications and infants physiological and behavioral stress responses will be assessed
Project 8 This study uses PET and fMRI to characterize the impact of early-life stress on functional neural pathways mediating mood reactivity self reference and reward-processing in patients with major depression Cortical-limbic-striatal changes in cases with early stress but no psychopathology that define vulnerability to depression are also identified
Project 9 This Project uses data obtained in Project 8 as well as diffusion tensor imaging to define the influence of early-life trauma on brain anatomical and functional connectivity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DATR A3-NSC | US NIH GrantContract | None | httpsreporternihgovquickSearchP50MH058922 |
| P50MH058922 | NIH | None | None |
| 572-2004 | None | None | None |