Ignite Creation Date:
2024-05-05 @ 12:00 PM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00202683
Status:
COMPLETED
Last Update Posted:
2007-05-17
First Post:
2005-09-16
Brief Title:
Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness
Sponsor:
Société Française de Cardiologie
Organization:
Société Française de Cardiologie
Study Overview
Official Title:
Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness Associated With Chemoreflex Failure
Status:
COMPLETED
Status Verified Date:
2007-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is is the first step of a full study named CHEMOGENE because it explores the genetic determinant of an alteration of the chemoreflex This reflex determines hyperventilation when the pressure of oxygen falls in the blood This happens when subjects travel to high-altitude where oxygen levels diminish in the atmosphere Subjects with such an altered chemoreflex are intolerant to altitude and develop pulmonary or cerebral edema associated with a severe headache In this study we compare subjects tolerant to high altitude 8000 metersto subjects intolerant to altitude The chemoreflex is measured ie the hyperventilation associated with hypoxia and all subjects are scanned for the genes implicated in the mitochondrial respiratory chain The idea is that subjects with an impaired oxygen sensing will exhibit an altered chemoreflex and will be intolerant to high-altitude
Detailed Description:
Subjects are selected at an outpatient clinic specialised in the diagnosis of tolerance to altitude where the chemoreflex is analyzed during a bicycle exercise performed with a oxygen deprived air simulating a 8000 meters altitude
All subjects will go later to high altitude for trekking usually The patients are those subjects with an altered chemoreflex who exhibited cerebral edema or pulmonary edema during the trekking
The controls are the subjects with a normal chemoreflex who did not exhibit any trouble during their journey
Fourty subjects of each group are included A blood sample is withdrawn and studied for succinate dehydrogenase genes in a blind fashion
After completing the inclusion the allelic mutations will be compared in the two groups
All subjects will go later to high altitude for trekking usually The patients are those subjects with an altered chemoreflex who exhibited cerebral edema or pulmonary edema during the trekking
The controls are the subjects with a normal chemoreflex who did not exhibit any trouble during their journey
Fourty subjects of each group are included A blood sample is withdrawn and studied for succinate dehydrogenase genes in a blind fashion
After completing the inclusion the allelic mutations will be compared in the two groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None