Ignite Creation Date:
2024-05-05 @ 12:00 PM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00208143
Status:
COMPLETED
Last Update Posted:
2007-12-13
First Post:
2005-09-13
Brief Title:
Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia
Sponsor:
Creighton University
Organization:
Creighton University
Study Overview
Official Title:
Seroquel Quetiapine Therapy for Schizophrenia and Schizoaffective Disorders and Comorbid Cocaine andor Amphetamine AbuseDependence A Comparative Study With Risperidone
Status:
COMPLETED
Status Verified Date:
2006-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
It is hypothesized that the atypical antipsychotic Seroquel will cause significant reduction in drug and alcohol cravings in patients with schizophrenia and comorbid cocaine andmethamphetamine dependence compared to the atypical antipsychotic risperidone Risperdal
Patients treated with Seroquel will have less use of cocaine andor methamphetamine as measured by the Time Line Follow-back over a 24-week follow-up period
Patients treated with Seroquel will have less use of cocaine andor methamphetamine as measured by the Time Line Follow-back over a 24-week follow-up period
Detailed Description:
Schizophrenia is a serious mental illness that afflicts approximately 1 of the population 1 Often these patients have comorbid cocaine and amphetamine dependence which increases the severity of psychotic symptoms associated with schizophrenia decreases treatment compliance and worsens prognosis
The treatment of schizophrenia with comorbid cocaine andor amphetamine dependence is complex and involves adherence to psychiatric medications most often antipsychotic agents along with participation in specific substance abuse treatment such as structured living attendance at self-help group meetings individual and group therapy and a commitment to sobriety In the absence of specific pharmacotherapy of cocaine and amphetamine dependence various antipsychotic medications have been compared to see if they impact comorbid cocaine and amphetamine abuse in addition to their antipsychotic effects
The primary objective of this study is to test whether Seroquel as a mono-therapy decreases cocaine andor methamphetamine use in patients with schizophrenia as compared to risperidone
The treatment of schizophrenia with comorbid cocaine andor amphetamine dependence is complex and involves adherence to psychiatric medications most often antipsychotic agents along with participation in specific substance abuse treatment such as structured living attendance at self-help group meetings individual and group therapy and a commitment to sobriety In the absence of specific pharmacotherapy of cocaine and amphetamine dependence various antipsychotic medications have been compared to see if they impact comorbid cocaine and amphetamine abuse in addition to their antipsychotic effects
The primary objective of this study is to test whether Seroquel as a mono-therapy decreases cocaine andor methamphetamine use in patients with schizophrenia as compared to risperidone
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None