Ignite Creation Date:
2024-05-05 @ 12:00 PM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00204984
Status:
COMPLETED
Last Update Posted:
2019-02-08
First Post:
2005-09-13
Brief Title:
Heart and Blood Pressure Study The Effect of Aortic Impedance on Myocardial Relaxation
Sponsor:
University of Wisconsin Madison
Organization:
University of Wisconsin Madison
Study Overview
Official Title:
The Effect of Aortic Impedance on Myocardial Relaxation
Status:
COMPLETED
Status Verified Date:
2019-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Does dilation of blood vessels vasodilation which decreases aortic stiffness have a greater effect on heart myocardium relaxation diastole than vasodilation which affects mean pressure equally without improving aortic stiffness
Detailed Description:
60 subjects 30 with hypertension and 30 without will attend two visits to the GCRC At each visit pulsatile hemodynamics by using tonometry-a non-invasive means to obtain arterial pressure tracings and Doppler tissue imaging relaxation velocity a measurement of myocardial relaxation obtained by echocardiography data will be collected before and after administration of vasodilator medication At the first visit each patient will receive an oral dose of the vasodilator hydralazine does not effect aortic stiffness and at the second visit each patient will receive intravenous nesiritide does effect aortic stiffness The relationship between timing of the reflected pulse wave and myocardial relaxation velocity will be studied at baseline and following administration of each vasodilator to determine if changing aortic stiffness has an impact on myocardial relaxation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| K23 AGO01022 | None | None | None |