Ignite Creation Date:
2024-05-05 @ 10:23 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005442
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Re-evaluating Triglycerides in Coronary Heart Disease
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To conduct a comprehensive epidemiologic investigation into the relationship between serum triglyceride TG levels and coronary heart disease CHD
Detailed Description:
BACKGROUND
The results of this investigation helped to shed substantial light on the controversial relationship between triglycerides and coronary heart disease a topic of great importance to preventive cardiology Additionally important methodological information was obtained in the study of interactions and precision of variables in epidemiologic analysis
DESIGN NARRATIVE
There were three components to the study 1 an analysis of several existing cardiovascular databases for evidence of a significant association between coronary heart disease and specific lipid interactions involving triglycerides 2 an analysis of these databases to investigate the role of measurement precision on the association between elevated triglyceride levels and coronary heart disease and 3 a survey of both expert lipidologists and community clinicians to examine current practices related to screening for and treatment of elevated triglyceride levels for the purpose of reducing coronary heart disease risk Five databases were used in the first two components of this study These data sets included those of the Lipid Research Clinics Prevalence and Mortality Follow-up Studies the Lipid Research Clinics Coronary Primary Prevention Trial the Multiple Risk Factor Intervention Trial the National Heart Lung and Blood Type II Coronary Intervention Study and the Coronary Drug Project For the first component detailed statistical analyses of all databases were performed specifically examining the role of lipid interactions involving triglycerides and their association with coronary heart disease For the second component more precise estimates of each subjects lipid levels were recalculated using the multiple lipid measurements already available in each database Each dataset was then analyzed for evidence of an independent relationship between triglycerides and coronary heart disease and to validate the theoretical findings suggesting that measurement imprecision may explain the difficulty of detecting an independent triglyceride-coronary heart disease association The public health implications of the current state of knowledge surrounding triglycerides were assessed with survey research techniques in the third component
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The results of this investigation helped to shed substantial light on the controversial relationship between triglycerides and coronary heart disease a topic of great importance to preventive cardiology Additionally important methodological information was obtained in the study of interactions and precision of variables in epidemiologic analysis
DESIGN NARRATIVE
There were three components to the study 1 an analysis of several existing cardiovascular databases for evidence of a significant association between coronary heart disease and specific lipid interactions involving triglycerides 2 an analysis of these databases to investigate the role of measurement precision on the association between elevated triglyceride levels and coronary heart disease and 3 a survey of both expert lipidologists and community clinicians to examine current practices related to screening for and treatment of elevated triglyceride levels for the purpose of reducing coronary heart disease risk Five databases were used in the first two components of this study These data sets included those of the Lipid Research Clinics Prevalence and Mortality Follow-up Studies the Lipid Research Clinics Coronary Primary Prevention Trial the Multiple Risk Factor Intervention Trial the National Heart Lung and Blood Type II Coronary Intervention Study and the Coronary Drug Project For the first component detailed statistical analyses of all databases were performed specifically examining the role of lipid interactions involving triglycerides and their association with coronary heart disease For the second component more precise estimates of each subjects lipid levels were recalculated using the multiple lipid measurements already available in each database Each dataset was then analyzed for evidence of an independent relationship between triglycerides and coronary heart disease and to validate the theoretical findings suggesting that measurement imprecision may explain the difficulty of detecting an independent triglyceride-coronary heart disease association The public health implications of the current state of knowledge surrounding triglycerides were assessed with survey research techniques in the third component
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R29HL051024 | NIH | None | httpsreporternihgovquickSearchR29HL051024 |