Ignite Creation Date:
2024-05-05 @ 10:23 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005911
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2000-06-13
Brief Title:
Magnetic Resonance Imaging to Study the Normal Eye
Sponsor:
National Eye Institute NEI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Refinement of the Magnetic Resonance Imaging Technique for the Study of the Normal Eye Particularly the Lens and Cataract
Status:
COMPLETED
Status Verified Date:
2002-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will assess the value of improved magnetic resonance imaging MRI techniques to study the lens of the human eye Knowledge of how cataracts develop and progress has been hampered by the lack of human tissue available for study MRI may provide an effective means for learning more about this eye disease
Normal volunteers between 18 and 70 years of age may be eligible for this study Participants will undergo a medical history and complete eye examination including vision assessment eye pressure measurement lens and retina examinations and photography of the eye
MRI scans will be scheduled for a second visit For this procedure the volunteers pupils are dilated and he or she then lies on a stretcher that is moved into a cylinder containing a magnetic field A device similar to a welders helmet is placed on the head Attached to the device are an imaging probe and a small blinking light The probe receives radio signals from the eye that a computer converts into images During imaging the participant gazes at the blinking light this helps keep the eyes from blinking and wandering Scan times vary from 2 to 10 minutes the total time for the study is less than an hour
Normal volunteers between 18 and 70 years of age may be eligible for this study Participants will undergo a medical history and complete eye examination including vision assessment eye pressure measurement lens and retina examinations and photography of the eye
MRI scans will be scheduled for a second visit For this procedure the volunteers pupils are dilated and he or she then lies on a stretcher that is moved into a cylinder containing a magnetic field A device similar to a welders helmet is placed on the head Attached to the device are an imaging probe and a small blinking light The probe receives radio signals from the eye that a computer converts into images During imaging the participant gazes at the blinking light this helps keep the eyes from blinking and wandering Scan times vary from 2 to 10 minutes the total time for the study is less than an hour
Detailed Description:
Studies of human diabetic cataract and age related cataract formation have been hampered by unavailability of human tissues especially in the early stages of the disease Eye bank tissues are first used for cornea transplants so that by the time they become available for basic research studies the lens is no longer suitable for biochemical nor histological studies Cataracts usually only become available after extraction which is at the end stage of their development However appropriate surgical lens specimens are no longer available because cataracts are generally extracted by the destructive phakoemulsification technique Therefore noninvasive techniques are required in order to study the lens in vivo
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-EI-0151 | None | None | None |