Ignite Creation Date:
2024-05-05 @ 12:01 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00216996
Status:
WITHDRAWN
Last Update Posted:
2016-11-16
First Post:
2005-09-20
Brief Title:
Effect of Glutamine Supplemented Nutrition Support on Protein and Glutamine Metabolism in Burns
Sponsor:
Massachusetts General Hospital
Organization:
Massachusetts General Hospital
Study Overview
Official Title:
Study on the Effect of Glutamine Supplemented Nutrition Support on Protein and Glutamine Metabolism in Severely Burned Patients
Status:
WITHDRAWN
Status Verified Date:
2016-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
This study was withdrawn see NCT00181753
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The Total Parenteral Nutrition TPNreceived as part of your routine burn care has optimal levels of protein and sugar however the best mixture of amino acids for a patient with burn wounds is not yet known Amino acids occur naturally in the body and the food we eat The body combines amino acids to make protein It uses the proteins to do things such as heal wounds fight infection and provide energy We are studying if the bodys use of protein is increased after receiving TPN containing the amino acid called glutamine We hope to learn the best composition of TPN so that the body can more efficiently repair wounded tissues and recover earlier from an acute burn injury
Detailed Description:
Human and animal studies have demonstrated that glutamine catabolism exceeds glutamine synthesis in burn patients resulting in a glutamine-depleted status which compromises liver function including glutathione status proline and arginine homeostasis and whole body protein balance 1 The purpose of this study is to directly quantify glutamine glutamate kinetics in relation to glutamine glutamate disposal and whole body amino acid balance by using stable isotope tracers 1-13C 15Nleucine and 15N2urea
We hypothesize that the enrichment of amino acid mixtures with glutamine will attenuate overall body nitrogen catabolism and better maintain proline and arginine homeostasis
The purpose of this study it to 1 investigate the effect of glutamine supplemented total parenteral nutrition TPN on whole body metabolic and disposal rate of glutamine and its rate of de novo synthesis in severely burned patients and 2explore the impact of glutamine supplementation on whole body protein turnover studied with L-1-13C 15N-leucine and on the metabolic homeostasis of urea cycle
We hypothesize that the enrichment of amino acid mixtures with glutamine will attenuate overall body nitrogen catabolism and better maintain proline and arginine homeostasis
The purpose of this study it to 1 investigate the effect of glutamine supplemented total parenteral nutrition TPN on whole body metabolic and disposal rate of glutamine and its rate of de novo synthesis in severely burned patients and 2explore the impact of glutamine supplementation on whole body protein turnover studied with L-1-13C 15N-leucine and on the metabolic homeostasis of urea cycle
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 5P50GM021700-26 | NIH | None | httpsreporternihgovquickSearch5P50GM021700-26 |