Ignite Creation Date:
2024-05-05 @ 12:01 PM
Last Modification Date:
2024-10-26 @ 9:18 AM
Study NCT ID:
NCT00211367
Status:
TERMINATED
Last Update Posted:
2007-06-21
First Post:
2005-09-13
Brief Title:
Treatment of Radiation Retinopathy With Open-Label Anecortave Acetate Sterile Suspension 15 mg
Sponsor:
Manhattan Eye Ear Throat Hospital
Organization:
Manhattan Eye Ear Throat Hospital
Study Overview
Official Title:
None
Status:
TERMINATED
Status Verified Date:
2007-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
poor enrollment
Has Expanded Access:
True
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Radiation retinopathy is a disease of the retina It occurs in people who have received or been exposed to radiation near the eyes The blood vessels are abnormal and may grow which lead to scarring and a loss of central vision Currently the treatment for radiation retinopathy is laser photocoagulation This treatment has been found to have limited use in this type of condition Compassionate use of anecortave acetate injection is being considered to prevent the growth of the blood vessels under the retina
Detailed Description:
Patients will receive an injection of 15 mg of Anecortave acetate behind the eye to be treated study eye They will be evaluated every six months to determine if their condition is stable or worse Following the injection of study medication patients will not be required to come in to see the study physician The investigator or study staff will call the patients on the day following injection to make sure there were no adverse effects to the injection Patients will then come in for a Month 1 and a Month 3 follow-up visit At the Month 3 follow-up visit if patients are not showing stability or improvement they may be offered either thermal laser or Photodynamic Therapy They will remain in the study and remain eligible for a repeat injection of Anecortave Acetate at the Month 6 visit
Patients will then been seen at Month 6 for a Re-treatment Evaluation Visit If their condition is stable they will be offered re-injection with the same study medication they received earlier If Patients are not showing stability or improvement at the Month 6 visit they may be offered thermal laser or Photodynamic Therapy in conjunction with the Anecortave Acetate injection
Patients will then come back again for a Month 1 and a Month 3 visit and an Exit Visit if necessary If the patients condition is worse patients will be exited from this study and offered standard treatment
Patients will then been seen at Month 6 for a Re-treatment Evaluation Visit If their condition is stable they will be offered re-injection with the same study medication they received earlier If Patients are not showing stability or improvement at the Month 6 visit they may be offered thermal laser or Photodynamic Therapy in conjunction with the Anecortave Acetate injection
Patients will then come back again for a Month 1 and a Month 3 visit and an Exit Visit if necessary If the patients condition is worse patients will be exited from this study and offered standard treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None