Ignite Creation Date:
2024-05-05 @ 12:01 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00216970
Status:
UNKNOWN
Last Update Posted:
2009-08-13
First Post:
2005-09-16
Brief Title:
Study of Arginine Metabolism and Nitric Oxide Formation in Relation to Glutamine Supply in Severely Burned Patients
Sponsor:
Massachusetts General Hospital
Organization:
National Institute of General Medical Sciences NIGMS
Study Overview
Official Title:
Study of Arginine Metabolism and Nitric Oxide Formation in Relation to Glutamine Supply in Severely Burned Patients
Status:
UNKNOWN
Status Verified Date:
2009-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the study is to understand the way the body uses amino acids and proteins in burned patient during the time they cannot eat normally This study aims to understand the metabolism of the amino acid arginine in the body after burn injury The results of this study will help determine the best composition of food needed during an acute burn injury so that body can more efficiently use the supplied nutrient for optimal burn wound healing and early recovery
Detailed Description:
The principle sources of plasma free arginine are i diet ii release from protein breakdown and iii de novo synthesis directly from citrulline and the recycling of orthinine via the urea cycle The major pathway of arginine disposal is ioxidation via orthinine glutamate and subsequently the Tricarboxylic Acid TCA cycle and iivia formation of nitric oxide The latter pathway plays an important regulatory role in the bodys response to stress and is significantly increased after burn injury
Previous studies with burn patients show ian increased rate of total arginine flux iia limited rate of arginine de novo synthesis and iii an apparent increase in the rate of arginine catabolism as measured indirectly by increased orinthine oxidation These changes render arginine a conditionally essential amino acid for burn patients Studies have shown that feeding glutamine to healthy adults significantly alters the blood concentrations of urea cycle intermediates arginine citrulline and orthinine Therefore we hypothesize that the availability of arginine can be improved in the burn patient by supplementing total parenteral nutrition TPN support with glutamine
Using stable isotope tracer studies our specific aims are
1 To explore the dynamic aspects of arginine and citrulline metabolism There will be an emphasis on arginine disposal via oxidation and urea nitrogen formation via nitric oxide production
2 To explore the effect of a depleting arginine and its immediate precursors proline and glutamine and bglutamine supplementation on the metabolic pathways of burn patients
3 To estimate the rate of nitric oxide NO formation in burn patients using arginine and citrulline tracers
Previous studies with burn patients show ian increased rate of total arginine flux iia limited rate of arginine de novo synthesis and iii an apparent increase in the rate of arginine catabolism as measured indirectly by increased orinthine oxidation These changes render arginine a conditionally essential amino acid for burn patients Studies have shown that feeding glutamine to healthy adults significantly alters the blood concentrations of urea cycle intermediates arginine citrulline and orthinine Therefore we hypothesize that the availability of arginine can be improved in the burn patient by supplementing total parenteral nutrition TPN support with glutamine
Using stable isotope tracer studies our specific aims are
1 To explore the dynamic aspects of arginine and citrulline metabolism There will be an emphasis on arginine disposal via oxidation and urea nitrogen formation via nitric oxide production
2 To explore the effect of a depleting arginine and its immediate precursors proline and glutamine and bglutamine supplementation on the metabolic pathways of burn patients
3 To estimate the rate of nitric oxide NO formation in burn patients using arginine and citrulline tracers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 5P50GM021700-28 | NIH | None | httpsreporternihgovquickSearch5P50GM021700-28 |