Ignite Creation Date:
2024-05-06 @ 8:13 AM
Last Modification Date:
2024-10-26 @ 11:57 AM
Study NCT ID:
NCT02690389
Status:
COMPLETED
Last Update Posted:
2016-02-24
First Post:
2016-01-28
Brief Title:
Electro-acupuncture and Flumazenils Effect on Sedation
Sponsor:
Dr Yin Liu
Organization:
Sichuan Cancer Hospital and Research Institute
Study Overview
Official Title:
The Sedation Effect of Electro-acupuncture on Bilateral Zusanli ST 36 and Neiguan PC 6 in General Anesthesia May Not be Mediated by the Benzodiazepines- GABA Pathway
Status:
COMPLETED
Status Verified Date:
2016-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EAFLUM
Brief Summary:
Object To explore the mechanism of the electro-acupuncture EA induced sedation effect in general anaesthesia through investigating the role of the Benzodiazepines-GABA system
Method 80 patients undergoing abdominal surgery were randomly divided into four groups n20 C group propofol only group F group propofol flumazenil group EA group propofol electro-acupuncture group and EAF group propofol electro-acupuncture flumazenil group Before induction acupuncture needles were inserted at the points of Zusanli ST 36 and Neiguan PC 6 bilaterally to elicitDeQi Target-controlled infusion TCI of propofol was used for the induction and maintenance of anaesthesia After 15minutes equilibrium of Narcotrend Index NT index was achieved patients were then assigned to receive different interventions In EA group and EAF group patients received EA for 30 minutes under general anaesthesia and flumazenil with the dosage of 01mgkg was added in the latter at the end of EA In C group and F group patients didnt receive EA and flumazenil with the dosage of 01mgkg was administered in F Group at the same time point with EAF group HR MAP and NT index were recorded at different time points up to 30 minutes after the end of EA
Method 80 patients undergoing abdominal surgery were randomly divided into four groups n20 C group propofol only group F group propofol flumazenil group EA group propofol electro-acupuncture group and EAF group propofol electro-acupuncture flumazenil group Before induction acupuncture needles were inserted at the points of Zusanli ST 36 and Neiguan PC 6 bilaterally to elicitDeQi Target-controlled infusion TCI of propofol was used for the induction and maintenance of anaesthesia After 15minutes equilibrium of Narcotrend Index NT index was achieved patients were then assigned to receive different interventions In EA group and EAF group patients received EA for 30 minutes under general anaesthesia and flumazenil with the dosage of 01mgkg was added in the latter at the end of EA In C group and F group patients didnt receive EA and flumazenil with the dosage of 01mgkg was administered in F Group at the same time point with EAF group HR MAP and NT index were recorded at different time points up to 30 minutes after the end of EA
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None