Ignite Creation Date:
2024-05-05 @ 10:23 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005287
Status:
COMPLETED
Last Update Posted:
2016-01-12
First Post:
2000-05-25
Brief Title:
Late Sequelae of Bronchopulmonary Dysplasia
Sponsor:
Stanford University
Organization:
Stanford University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2016-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To measure the cardiopulmonary function in individuals who developed bronchopulmonary dysplasia BPD at Stanford University Medical Center from 1964-1973 and to determine the factors associated with the presence of cardiopulmonary function abnormalities in these adolescents and young adults
Detailed Description:
BACKGROUND
Eleven to 22 percent of prematurely born human infants with Respiratory Distress Syndrome RDS treated with artificial ventilation and supplemental oxygen therapy develop a severe chronic lung disease called bronchopulmonary dysplasia While many children who had BPD are asymptomatic by three years of age some can have respiratory symptoms and abnormal pulmonary function tests at nine years of age The hypothesis tested in this study is that abnormalities of pulmonary function seen in infants with BPD can persist into adolescence even in asymptomatic children and young adults
DESIGN NARRATIVE
A detailed interval pulmonary history was taken Pulmonary abnormalities were determined by pulmonary angiography and lateral chest x-ray and pulmonary function tests for small airway obstruction reversible bronchial hyperreactivity distribution of ventilation air trapping and hyperinflation residual interstitial disease or edema vascular bed loss and gas exchange Right and left ventricular hypertrophy were evaluated by electrocardiogram Elevated right ventricular pressure was estimated by echocardiography with doppler ultrasound The atopic status of the children was determined Other abnormalities including growth retardation developmental delay hearing loss retrolental fibroplasia and neurologic disability seen in BPD were assessed by history and physical examination
Eleven to 22 percent of prematurely born human infants with Respiratory Distress Syndrome RDS treated with artificial ventilation and supplemental oxygen therapy develop a severe chronic lung disease called bronchopulmonary dysplasia While many children who had BPD are asymptomatic by three years of age some can have respiratory symptoms and abnormal pulmonary function tests at nine years of age The hypothesis tested in this study is that abnormalities of pulmonary function seen in infants with BPD can persist into adolescence even in asymptomatic children and young adults
DESIGN NARRATIVE
A detailed interval pulmonary history was taken Pulmonary abnormalities were determined by pulmonary angiography and lateral chest x-ray and pulmonary function tests for small airway obstruction reversible bronchial hyperreactivity distribution of ventilation air trapping and hyperinflation residual interstitial disease or edema vascular bed loss and gas exchange Right and left ventricular hypertrophy were evaluated by electrocardiogram Elevated right ventricular pressure was estimated by echocardiography with doppler ultrasound The atopic status of the children was determined Other abnormalities including growth retardation developmental delay hearing loss retrolental fibroplasia and neurologic disability seen in BPD were assessed by history and physical examination
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL036796 | NIH | None | httpsreporternihgovquickSearchR01HL036796 |