Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00226551
Status:
COMPLETED
Last Update Posted:
2008-10-29
First Post:
2005-09-12
Brief Title:
Vascular Response to Isoproterenol and β2 Adrenergic Receptor Polymorphisms
Sponsor:
Hadassah Medical Organization
Organization:
Hadassah Medical Organization
Study Overview
Official Title:
ß2 Adrenergic Receptor Polymorphisms and Vasodilation of Internal Mammary Artery Induced by Isoproterenol
Status:
COMPLETED
Status Verified Date:
2008-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Single nucleotide polymorphisms at codon 46 and 79 of the gene encoding for the ß2 adrenergic receptor ß2AR modify its pharmacological properties and may alter the response to ß2AR agonists The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo
Internal mammary leftover segments were collected from 96 patients undergoing coronary artery bypass graft operation Four rings that were prepared from each specimen were allowed to reach equilibrium with physiological Krebs solution prior to precontraction with U46619 Using the organ bath technique cumulative dose response curve of isoproterenol was constructed and mean EC50 calculated for each patient
Internal mammary leftover segments were collected from 96 patients undergoing coronary artery bypass graft operation Four rings that were prepared from each specimen were allowed to reach equilibrium with physiological Krebs solution prior to precontraction with U46619 Using the organ bath technique cumulative dose response curve of isoproterenol was constructed and mean EC50 calculated for each patient
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None