Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00222768
Status:
COMPLETED
Last Update Posted:
2008-02-18
First Post:
2005-09-19
Brief Title:
PET Imaging of Regional Variation in Insulin Sensitivity of Adipose Tissue in Humans
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Three-Tracer PET Quantitation of Insulin Action in Muscle
Status:
COMPLETED
Status Verified Date:
2008-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this research study is to use a relatively new technology called Positron Emission Tomography PET to study how insulin works on sugar in your bodys fatty tissue PET imaging is a way of obtaining a metabolic image of your internal organs It does not involve surgery and is not a high risk process It has been used successfully to study brain heart and more recently skeletal muscle In this research study we will use PET in combination with Magnetic Resonance Imaging MRI to study fatty tissues in healthy people who do not have diabetes In the future we plan to do similar PETMRI studies in individuals with type 2 diabetes mellitus T2DM and in individuals who are likely to develop T2DM
Fat tissue might have a lot to do with developing type 2 diabetes First it is well recognized that excess fatty tissues especially the kind in your belly increases risk for the development of T2DM as well as affecting other ways the body uses insulin Second fatty tissue is a classic target tissue for the action of insulin which regulates the use of sugar by fat cells and also regulates the release of fatty acids from fatty tissues Third studies in mice that lack fatty tissue indicate that severe insulin resistance lack of a normal response to insulin can result Other types of studies have shown that fatty tissues make proteins that affect your bodys insulin and your appetite in good and bad ways Yet despite this importance we still lack techniques for the study of fatty tissue metabolism in humans
Fat tissue might have a lot to do with developing type 2 diabetes First it is well recognized that excess fatty tissues especially the kind in your belly increases risk for the development of T2DM as well as affecting other ways the body uses insulin Second fatty tissue is a classic target tissue for the action of insulin which regulates the use of sugar by fat cells and also regulates the release of fatty acids from fatty tissues Third studies in mice that lack fatty tissue indicate that severe insulin resistance lack of a normal response to insulin can result Other types of studies have shown that fatty tissues make proteins that affect your bodys insulin and your appetite in good and bad ways Yet despite this importance we still lack techniques for the study of fatty tissue metabolism in humans
Detailed Description:
The association of adiposity with insulin resistance IR is modulated by regional fat deposition For example visceral intra-abdominal adipose tissue VAT is generally regarded as more strongly correlated with IR than subcutaneous adiposity of the thigh ThiSAT or abdomen AbdSAT even though these latter depots are larger than VAT Perhaps these differences are due to regional variation in AT metabolism A limitation of body composition methods is that these assess amount rather than metabolism of adipose tissue AT Our aim is to use positron emission tomography PET imaging with F-18 fluorodeoxyglucose FDG for the in vivo investigation of AT metabolism and use this in conjunction with regional body composition imaging so that both the amount of AT and metabolism of AT can be determined Hopefully such an approach will give new insight as to how AT influences skeletal muscle and hepatic IR The current project seeks to develop this approach generating preliminary data to lay a foundation for subsequent projects
The first specific aim is conduct dose-responsive measurement of insulin-stimulated glucose uptake ie insulin sensitivity of AT in humans using PET imaging in healthy volunteers We will examine the effects of insulin infusion rates at 0 20 and 80 mUmin-m2 body surface area
The second specific aim is to assess regional variation in insulin-stimulated glucose uptake in AT comparing VAT AbdSAT and ThiSAT in volunteers without IR We will test the hypothesis that insulin sensitivity IS follows the rank order of ThiSAT IS AbdSAT IS VAT IS
At any given body mass index fat mass constitutes a higher percentage of body weight in women than men The third specific aim is to assess potential gender-differences in AT metabolism testing the hypothesis that AT IS is greater in women than men
The first specific aim is conduct dose-responsive measurement of insulin-stimulated glucose uptake ie insulin sensitivity of AT in humans using PET imaging in healthy volunteers We will examine the effects of insulin infusion rates at 0 20 and 80 mUmin-m2 body surface area
The second specific aim is to assess regional variation in insulin-stimulated glucose uptake in AT comparing VAT AbdSAT and ThiSAT in volunteers without IR We will test the hypothesis that insulin sensitivity IS follows the rank order of ThiSAT IS AbdSAT IS VAT IS
At any given body mass index fat mass constitutes a higher percentage of body weight in women than men The third specific aim is to assess potential gender-differences in AT metabolism testing the hypothesis that AT IS is greater in women than men
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DK060555 | NIH | None | httpsreporternihgovquickSearchR01DK060555 |