Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00222924
Status:
COMPLETED
Last Update Posted:
2007-12-19
First Post:
2005-09-20
Brief Title:
Mitochondrial Impairment in Muscle Insulin Resistance
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Mitochondrial Impairment in Muscle Insulin Resistance
Status:
COMPLETED
Status Verified Date:
2007-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This investigation is being carried out to learn more about research findings from a study that was completed last year Those findings revealed that within the skeletal muscle cells of individuals with type 2 diabetes there was often damage to the mitochondria the muscle cells power source or the machinery of the muscle cell that produces energy In individuals with type 2 diabetes the liver continues to release sugar even when sugar levels are normal the pancreas is not able to produce and release insulin normally and the muscle and fat cells no longer respond as effectively to insulin These defects lead to an abnormal rise of sugar in the blood In this study we want both to look more closely at the mitochondria and see if there is potential for improving mitochondrial functioning improving the machinery of the muscle cell that produces energy and reversing mitochondrial damage through a weight loss or a combined exerciseweight loss program The program you get assigned to will be determined by a process called randomization like a flip of a coin
Detailed Description:
Recent research from our laboratory has detected novel findings concerning damage to mitochondria within skeletal muscle in type 2 diabetes type 2 DM damage that is evident morphologically and by functional criteria In this project we propose firstly to more fully test this hypothesis of an impaired bio-energetic capacity and to begin to examine the pathogenesis of damage to mitochondria in type 2 DM We are also interested in assessing the potential for reversing damage and improving functional capacity of mitochondria through a weight loss or a combined exercise and weight loss intervention
The first specific aim is to measure the functional capacity of mitochondria in human skeletal muscle in type 2 DM and in those at apparent risk for type 2 DM obese sedentary non-diabetic adults with the Metabolic Syndrome andor impaired glucose tolerance The second specific aim is to examine the morphology of mitochondria in human skeletal muscle in type 2 DM and in those at apparent risk for type 2 DM The third specific aim is to examine the pathogenesis of mitochondrial damage in type 2 DM and in those at apparent risk for type 2 DM The fourth specific aim is to assess whether exercise and diet can improve mitochondrial function and morphology in type 2 DM and in those at apparent risk for type 2 DM
The first specific aim is to measure the functional capacity of mitochondria in human skeletal muscle in type 2 DM and in those at apparent risk for type 2 DM obese sedentary non-diabetic adults with the Metabolic Syndrome andor impaired glucose tolerance The second specific aim is to examine the morphology of mitochondria in human skeletal muscle in type 2 DM and in those at apparent risk for type 2 DM The third specific aim is to examine the pathogenesis of mitochondrial damage in type 2 DM and in those at apparent risk for type 2 DM The fourth specific aim is to assess whether exercise and diet can improve mitochondrial function and morphology in type 2 DM and in those at apparent risk for type 2 DM
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DK049200 | NIH | None | httpsreporternihgovquickSearchR01DK049200 |