Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00221923
Status:
UNKNOWN
Last Update Posted:
2021-07-06
First Post:
2005-09-14
Brief Title:
African Descent and Glaucoma Evaluation Study
Sponsor:
University of California San Diego
Organization:
University of California San Diego
Study Overview
Official Title:
African Descent and Glaucoma Evaluation Study Formerly African Americans With Glaucoma Study
Status:
UNKNOWN
Status Verified Date:
2021-07
Last Known Status:
ENROLLING_BY_INVITATION
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ADAGES
Brief Summary:
According to the National Eye Institute Glaucoma affects about three million Americans Among Blacks in the United States open- angle glaucoma is the leading cause of irreversible visual loss Glaucoma is four times more likely to develop in Blacks than in Whites
This is a prospective longitudinal multi- site observational cohort study designed to obtain visual function and optic nerve structure data on eyes of Black and White Americans The investigators will evaluate the relationship between changes in the structure of the eye and the vision loss caused by glaucomaThis is the first study where both populations are matched for quality of care and equal access to care
This is a prospective longitudinal multi- site observational cohort study designed to obtain visual function and optic nerve structure data on eyes of Black and White Americans The investigators will evaluate the relationship between changes in the structure of the eye and the vision loss caused by glaucomaThis is the first study where both populations are matched for quality of care and equal access to care
Detailed Description:
The purpose of the study is
1 To further determine the nature of vision loss and optic nerve structural change associated with glaucoma Using recently developed measures of visual function and techniques for imaging the eye we will use a multivariate approach for analysis of the functional and structural changes associated with glaucoma to delineate further the relationship of these changes to the underlying physiological mechanisms
2 To evaluate and improve new diagnostic and monitoring techniques encompassing measures of visual function and optic nerve and retina nerve fiber layer structure and to compare the rate and patterns of progression of glaucomatous damage in Black and White eyes
3 To improve techniques for evaluation of current management and new therapies for glaucoma as they become available We will expand our analysis using multivariate techniques incorporating visual function optic nerve structure and various risk factors to improve detection of true change We will determine whether the benefits found in Whites using visual function specific perimetry and optic disc imaging for earlier detection and for monitoring progression are also found for Blacks
4 To determine the quantitative temporal relationships between recognizable optic nerve damage and measurable visual field loss and how these relationships differ among Black and White patients Using new techniques with improved sensitivity the detection and monitoring of early optic disc defects may provide profiles of people at risk for developing glaucomatous visual function loss thus better defining target populations for treatment
1 To further determine the nature of vision loss and optic nerve structural change associated with glaucoma Using recently developed measures of visual function and techniques for imaging the eye we will use a multivariate approach for analysis of the functional and structural changes associated with glaucoma to delineate further the relationship of these changes to the underlying physiological mechanisms
2 To evaluate and improve new diagnostic and monitoring techniques encompassing measures of visual function and optic nerve and retina nerve fiber layer structure and to compare the rate and patterns of progression of glaucomatous damage in Black and White eyes
3 To improve techniques for evaluation of current management and new therapies for glaucoma as they become available We will expand our analysis using multivariate techniques incorporating visual function optic nerve structure and various risk factors to improve detection of true change We will determine whether the benefits found in Whites using visual function specific perimetry and optic disc imaging for earlier detection and for monitoring progression are also found for Blacks
4 To determine the quantitative temporal relationships between recognizable optic nerve damage and measurable visual field loss and how these relationships differ among Black and White patients Using new techniques with improved sensitivity the detection and monitoring of early optic disc defects may provide profiles of people at risk for developing glaucomatous visual function loss thus better defining target populations for treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01EY026574 | NIH | None | httpsreporternihgovquickSearchR01EY026574 |
| R01EY023704 | NIH | None | None |