Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00221676
Status:
COMPLETED
Last Update Posted:
2006-11-28
First Post:
2005-09-13
Brief Title:
Effectiveness of Influenza Vaccination Among General Practitioners
Sponsor:
University Hospital Antwerp
Organization:
University Hospital Antwerp
Study Overview
Official Title:
Effectiveness of Influenza Vaccination Alfarixin Preventing Clinical Influenza Cases Among General Practitioners Non-Randomized Clinical Trial
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Besides the personal protection influenza vaccination especially needs to prevent transmission of influenza between GPs and their patients The question remains if the vaccine is adding substantial benefit to the natural acquired immunity of GPs Doubts are raised if an inactivated vaccine which elicit especially humoral immune response can give enough protection against virus replication and subclinical influenza infections Until now no effectiveness studies of influenza vaccination were performed among GPs This study will assess the effectiveness of an inactivated influenza vaccine in GPs against clinical respiratory tract infections and more particular against influenza cases with influenza positive nose and throat swabs diagnosed by RT-PCR
Detailed Description:
Two important aspects emerge when considering influenza vaccination of general practitioners as advocated by many guidelines Besides the personal protection the vaccine especially needs to prevent transmission of influenza between GPs and their patients In long-term elderly hospitals a possible benefit of influenza vaccination of the healthcare workers was noticed in reducing mortality among the elderly But this specific situation is not fully transmissible to the general practice
GPs having yearly close contact with several influenza cases built up a high basic immunity and probably only suffer from minor symptoms The question remains if the vaccine is adding substantial benefit to this natural acquired immunity In addition doubts are raised in the literature if an inactivated vaccine which elicit especially humoral immune response can give enough protection against virus replication and subclinical influenza infections Until now no effectiveness studies of influenza vaccination were performed among GPs High time to look more closer to these issues
Comparisons the effectiveness of an inactivated influenza vaccine compared with no vaccine in GPs against clinical respiratory tract infections and more particular against influenza cases with influenza positive nose and throat swabs diagnosed by RT-PCR besides serological defined influenza cases and taking important independent variables into account
GPs having yearly close contact with several influenza cases built up a high basic immunity and probably only suffer from minor symptoms The question remains if the vaccine is adding substantial benefit to this natural acquired immunity In addition doubts are raised in the literature if an inactivated vaccine which elicit especially humoral immune response can give enough protection against virus replication and subclinical influenza infections Until now no effectiveness studies of influenza vaccination were performed among GPs High time to look more closer to these issues
Comparisons the effectiveness of an inactivated influenza vaccine compared with no vaccine in GPs against clinical respiratory tract infections and more particular against influenza cases with influenza positive nose and throat swabs diagnosed by RT-PCR besides serological defined influenza cases and taking important independent variables into account
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None