Ignite Creation Date:
2024-05-05 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00227058
Status:
COMPLETED
Last Update Posted:
2007-01-26
First Post:
2005-09-23
Brief Title:
Effects of Orotic Acid Derivatives With or Without Glutathione on Allergic Rhinitis
Sponsor:
University of Mississippi Medical Center
Organization:
University of Mississippi Medical Center
Study Overview
Official Title:
Effects of Orotic Acid Derivatives With or Without Glutathione on Allergic
Status:
COMPLETED
Status Verified Date:
2007-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to learn if two nutritional supplements Orotic Acid and Glutathione will have any effect on the immune system response and if there will be any effect on the symptoms of seasonal allergies It is our thinking that they will have an positive effect
Detailed Description:
Current therapy for most immune-based diseases center around the use of anti inflammatory agents many of which have unpleasant or dangerous side effects Allergic rhinitis affects over 40 million Americans and its morbidity results from a combination of physical and psychological symptoms The primary immunopathology has been defined as an imbalance of TH1TH2 cytokines production resulting in increased allergen-specific IgE production mast cell activation and eosinophil recruitmentactivity Metallic salts of orotic acid OR a natural intermediate in pyrimidine nucleic acid synthesis have been utilized to improve the signs and symptoms of a variety of maladies including the common cold allergies and as preventatives for cancer and heart disease Recent studies have reported that moderate doses of OR can mitigate or prevent endocrine and subjective psychological stresses in an acute laboratory stress model All these findings lead us to hypothesize that OR salts administration will alleviate or eliminate the signs and symptoms associated with seasonal AR through a protective effect that involves direct anti-inflammatory immune effects andor immunomodulation that include leukocyte trafficking immunoregulatory cytokine balance andor decrease inflammatory cell activity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None