Ignite Creation Date:
2024-05-06 @ 8:32 AM
Last Modification Date:
2024-10-26 @ 12:01 PM
Study NCT ID:
NCT02750735
Status:
COMPLETED
Last Update Posted:
2016-04-25
First Post:
2016-04-15
Brief Title:
Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity
Sponsor:
University of Palermo
Organization:
University of Palermo
Study Overview
Official Title:
Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity
Status:
COMPLETED
Status Verified Date:
2016-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In the last few years a new clinical entity has emerged which includes patients who consider themselves to be suffering from problems caused by wheat andor gluten ingestion even though they do not have celiac disease CD or wheat allergy This clinical condition has been named non-celiac gluten sensitivity NCGS although in a recent article the investigators suggested the term non-celiac wheat sensitivity NCWS because it is not known to date what component of wheat actually causes the symptoms Nickel is the fourth most used metal and the most frequent cause of contact allergy in the industrialized world As a natural element of the earths crust small amounts are found in water soil and natural foods especially plant ones Nickel allergy not only affects the skin but also results in systemic manifestations Systemic nickel allergy syndrome can have cutaneous urticariaangioedema flares itching andor gastrointestinal meteorism colic diarrhoea signs and symptoms In this study the investigators evaluated 1 the frequency of Nickel allergy and Systemic Nickel allergy syndrome in NCWS patients and 2 the clinical serological and histological characteristics of NCWS patients with contact dermatitis Nickel positive in comparison to NCWS patients without contact dermatitis
Detailed Description:
In the last few years a new clinical entity has emerged which includes patients who consider themselves to be suffering from problems caused by wheat andor gluten ingestion even though they do not have celiac disease CD or wheat allergy This clinical condition has been named non-celiac gluten sensitivity NCGS although in a recent article the investigators suggested the term non-celiac wheat sensitivity NCWS because it is not known to date what component of wheat actually causes the symptoms Other areas of doubt in NCWS regard its pathogenesis while some papers reported intestinal immunologic activation others linked NCWS to the dietary short chain carbohydrate fermentable oligo-di-monosaccharides and polyols FODMAPs load The investigators recently demonstrated that higher proportions of patients with NCWS develop autoimmune disorders are antinuclear antibodies ANA positive and show DQ2DQ8 haplotypes compared with patients with irritable bowel syndrome IBS supporting an immunologic involvement in NCWS Furthermore some papers reported also a high frequency ranging from 22 and 35 of coexistent atopic diseases in NCWS patients and the investigators suggested that a percentage of NCWS patients could really suffer from non-IgE-mediated wheat allergy
Nickel is the fourth most used metal and the most frequent cause of contact allergy in the industrialized world As a natural element of the earths crust small amounts are found in water soil and natural foods especially plant ones Nickel allergy not only affects the skin but also results in systemic manifestations Systemic nickel allergy syndrome can have cutaneous urticariaangioedema flares itching andor gastrointestinal meteorism colic diarrhoea signs and symptoms
Volta et al reported that 15 of NCWS patients suffered from allergy to nickel but they did not further characterize this subgroup of patients neither posed the NCWS diagnosis by means the double-blind placebo controlled challenge DBPCC as recommended In this study the investigators evaluated 1 the frequency of Nickel allergy and Systemic Nickel allergy syndrome in NCWS patients and 2 the clinical serological and histological characteristics of NCWS patients with contact dermatitis Nickel positive in comparison to NCWS patients without contact dermatitis
Nickel is the fourth most used metal and the most frequent cause of contact allergy in the industrialized world As a natural element of the earths crust small amounts are found in water soil and natural foods especially plant ones Nickel allergy not only affects the skin but also results in systemic manifestations Systemic nickel allergy syndrome can have cutaneous urticariaangioedema flares itching andor gastrointestinal meteorism colic diarrhoea signs and symptoms
Volta et al reported that 15 of NCWS patients suffered from allergy to nickel but they did not further characterize this subgroup of patients neither posed the NCWS diagnosis by means the double-blind placebo controlled challenge DBPCC as recommended In this study the investigators evaluated 1 the frequency of Nickel allergy and Systemic Nickel allergy syndrome in NCWS patients and 2 the clinical serological and histological characteristics of NCWS patients with contact dermatitis Nickel positive in comparison to NCWS patients without contact dermatitis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None