Ignite Creation Date:
2024-05-05 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00225355
Status:
TERMINATED
Last Update Posted:
2009-02-19
First Post:
2005-09-21
Brief Title:
Rosiglitazone Versus Placebo in Chronic Stable Angina
Sponsor:
University of Glasgow
Organization:
University of Glasgow
Study Overview
Official Title:
Insulin Sensitisation as a Novel Mechanism to Lessen Ischaemic Burden in Overweight Non-Diabetic Patients With Chronic Stable Angina A Pilot Study
Status:
TERMINATED
Status Verified Date:
2009-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We wish to see if the drug rosiglitazone currently used in the treatment of type 2 diabetes could be used as a new treatment for angina when compared with placebo in overweight subjects who do not have overt diabetes The drug will be given for 3 months and the subjects will be have their angina tested by way of exercise testing angina quality of life questionnaire and 24-hour ECG monitoring before and after using the drug
Detailed Description:
Chronic stable angina is a common manifestation of ischaemic heart disease Current mechanical therapies percutaneous coronary intervention and coronary artery bypass grafting and pharmacological therapies nitrates calcium channel blockers betablockers and potassium channel activators main actions are to treat the end product of ischaemic heart disease on chronic stable angina ie the flow limiting stenosis We postulate that by treating insulin resistance an upstream factor in the pathogenesis of ischaemic heart disease we will improve angina by in turn improving endothelial function We will attempt to demonstrate this by way of full bruce protocol exercise tolerance test Seattle Angina Questionnaire and 24 hour ST segment analysis before and after treatment with the insulin sensitiser rosiglitazone for three months
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| Eudract no 2004-000949-38 | None | None | None |