Ignite Creation Date:
2024-05-06 @ 8:34 AM
Last Modification Date:
2024-10-26 @ 12:02 PM
Study NCT ID:
NCT02767323
Status:
COMPLETED
Last Update Posted:
2021-04-05
First Post:
2016-05-05
Brief Title:
Using TMS to Increase Executive Function in Older Adults
Sponsor:
Duke University
Organization:
Duke University
Study Overview
Official Title:
Using fMRI-guided TMS to Increase Central Executive Function in Older Adults
Status:
COMPLETED
Status Verified Date:
2021-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
WMTMS
Brief Summary:
Cognitive decline and dementia have become important public health issues in our time as medical science has increased lifespan and our society becomes progressively older A great deal of the cognitive decline due to aging can be explained by decline in working memory WM a mental function central to cognition in which aging deficits appear almost universally Attempts to use WM training to increase WM ability in older adults has had some success but the transfer of performance enhancements caused by this training to other cognitive skills is controversial Another intervention that shows much promise is noninvasive stimulation of cerebral cortex using transcranial magnetic stimulation TMS which has been shown to increase performance in many cognitive tasks
Here the investigator proposes to use fMRI-guided rTMS to enhance working memory performance This will be achieved through three Aims In the first registered on this record the investigator will stimulate both old and young healthy adults while they perform the WM task that will engage the frontoparietal network To define the optimal rTMS target rTMS will be applied over the dorsolateral prefrontal cortex DLPFC Aim 1a or over the parietal cortex PC Aim 1b These regions are involved not only in the maintenance of items in WM but also in their manipulation therefore applying rTMS over these areas should create WM performance enhancements that will be long-lasting In Aim 1c a direct within-subject comparison of these 2 targeted sites is performed
In the second and third Aims older adults will receive active or sham rTMS over the optimal target defined in Arm 1 during two weeks of daily sessions while they perform the WM tasks In the second Aim the investigator hopes to demonstrate that the cumulative effect of multiple TMS sessions in tandem with the synergistic effects of simultaneous TMS WM training create WM performance enhancements greater than those found with WM training alone whose effects are long-lasting continuing a month following the course of TMS sessions In the third the investigator will investigate whether the WM enhancements generated by the two weeks of TMS sessions will generalize to other cognitive tasks The success of these 3 Aims will provide proof in principle for long-lasting transferable effects of TMS in remediating WM and more general cognitive deficits due to aging and point to a possible non-invasive brain stimulation therapy for cognitive decline in healthy aging and in dementia This record is a reflection of Aim1 Aim 2 and 3 will be registered separately
Here the investigator proposes to use fMRI-guided rTMS to enhance working memory performance This will be achieved through three Aims In the first registered on this record the investigator will stimulate both old and young healthy adults while they perform the WM task that will engage the frontoparietal network To define the optimal rTMS target rTMS will be applied over the dorsolateral prefrontal cortex DLPFC Aim 1a or over the parietal cortex PC Aim 1b These regions are involved not only in the maintenance of items in WM but also in their manipulation therefore applying rTMS over these areas should create WM performance enhancements that will be long-lasting In Aim 1c a direct within-subject comparison of these 2 targeted sites is performed
In the second and third Aims older adults will receive active or sham rTMS over the optimal target defined in Arm 1 during two weeks of daily sessions while they perform the WM tasks In the second Aim the investigator hopes to demonstrate that the cumulative effect of multiple TMS sessions in tandem with the synergistic effects of simultaneous TMS WM training create WM performance enhancements greater than those found with WM training alone whose effects are long-lasting continuing a month following the course of TMS sessions In the third the investigator will investigate whether the WM enhancements generated by the two weeks of TMS sessions will generalize to other cognitive tasks The success of these 3 Aims will provide proof in principle for long-lasting transferable effects of TMS in remediating WM and more general cognitive deficits due to aging and point to a possible non-invasive brain stimulation therapy for cognitive decline in healthy aging and in dementia This record is a reflection of Aim1 Aim 2 and 3 will be registered separately
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01AG050618-01 | NIH | None | httpsreporternihgovquickSearch1R01AG050618-01 |