Ignite Creation Date:
2024-05-05 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00223054
Status:
COMPLETED
Last Update Posted:
2011-08-04
First Post:
2005-09-14
Brief Title:
Polymorphism of the Cytochrome P450-system in Renal Transplants
Sponsor:
University Hospital Schleswig-Holstein
Organization:
University Hospital Schleswig-Holstein
Study Overview
Official Title:
Polymorphism of the Cytochrome P450-system and the MDR-system in Renal Transplants Receiving the Immunosuppressive Drugs Tacrolimus Sirolimus Everolimus or Cyclosporine A
Status:
COMPLETED
Status Verified Date:
2008-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study the researchers want to investigate genetic polymorphisms of cytochrome 450 enzymes and the multiple drug resistance MDR gene in renal transplant patients to look for differences in dosing of immunosuppressive drugs tacrolimus sirolimus everolimus cyclosporine A
All patients who receive one of these drugs can be included and drug blood trough levels dosing and genetics are compared
All patients who receive one of these drugs can be included and drug blood trough levels dosing and genetics are compared
Detailed Description:
Primary endpoint is the
1 serum creatinine in patients with and without polymorphysms
2 rate of rejections in patients with and without polymorphysms
1 serum creatinine in patients with and without polymorphysms
2 rate of rejections in patients with and without polymorphysms
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None