Ignite Creation Date:
2024-05-05 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00224302
Status:
COMPLETED
Last Update Posted:
2008-06-04
First Post:
2005-09-15
Brief Title:
Treatment of MDEs During the Course of Psychotic Disorders With Duloxetine
Sponsor:
Central Institute of Mental Health Mannheim
Organization:
Central Institute of Mental Health Mannheim
Study Overview
Official Title:
Treatment of Major Depressive Episodes During the Course of Psychotic Disorders With Duloxetine
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We evaluate the efficacy and tolerability of duloxetine in the treatment of major depressive episodes during the course of psychotic disorders
Detailed Description:
Major depressive episodes MDE frequently occur during the course of schizophrenic psychoses both as as post-psychotic depressions and also independently from psychotic episodes A number of clinical studies reported the application of different antidepressive substances such as Imipramine Reboxetine or Venlafaxine In general the treatment of schizophrenic patients with antidepressive drugs can be considered as necessary and save resulting in therapeutic guidelines of different psychiatric societies However since 5 to 10 of the schizophrenic patients commit suicide there is still much effort necessary in order to improve the treatment of affective symptoms in schizophrenic psychosesThe recently introduced antidepressive substance Duloxetine selectively inhibits as a SSNRI the reuptake of serotonine and noradrenaline from the synaptic cleft Duloxetine was proven as antidepressive anxiolytic and analgetic in a series of multi-centre placebo-controlled investigations Based on these considerations and on successful experiences in single case reports we aim to investigate the therapeutic effects of duloxetine in patients with lifetime diagnoses of the schizophrenic spectrum
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None