Ignite Creation Date:
2024-05-05 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00229814
Status:
WITHDRAWN
Last Update Posted:
2012-09-24
First Post:
2005-09-12
Brief Title:
Study of Brain Tumors Tectal Tumors Using Magnetic Resonance Imaging
Sponsor:
Childrens Healthcare of Atlanta
Organization:
Childrens Healthcare of Atlanta
Study Overview
Official Title:
Magnetic Resonance Spectroscopic Analysis of Pediatric Tectal Tumors Insight Into Pathology and Behavior
Status:
WITHDRAWN
Status Verified Date:
2012-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
There were technical difficulties and the study was terminated in 2008
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Tectal plate gliomas are relatively rare tumors of childhood with a reported incidence of 10 Their typical clinical presentation is symptoms and signs of hydrocephalus and are often incidentally diagnosed in the imaging work-up of children with hydrocephalus Tectal tumors in children comprise a subcategory of brainstem tumors with unique clinical imaging and spectroscopic features There is debate whether they truly represent brainstem tumors or whether they are a site of benign cellular overgrowth The majority of these tumors are pathologically benign and show no or minimal growth Not all tectal plate tumors however have this typically benign course Some can manifest a more aggressive behavior There have been reports in the past attempting to analyze the histology and behavior of these tumors None of the prior series looking at these tumors have included Magnetic Resonance Spectroscopy MRS analysis
It is interesting that according to where tumors occur in the brainstem usually indicates what their histology and behavior is Although not absolute we know that tumors can have a very poor prognosis versus an extremely good prognosis depending on their location in the brainstem Yet there are always the cases that do not act in the typical fashion and this is where MRS can prove helpful
This study is being done to look at a region of the brain called the tectal plate in children This part of the brain can be involved by tumors Because of the location of the tectal plate it is usually very difficult and risky to get a biopsy tissue sample from this area Magnetic Resonance Spectroscopy MRS is a non-invasive imaging technique that can look at the chemical make up of the brain MRS may allow us to better understand the nature and behavior of these tumors However in order to understand disease in this area we need to look at the normal chemical make up of the brain in children without tectal plate tumors Healthy patients are being asked to participate as a normal volunteer We anticipate having a total of 10 to 12 normal volunteers in the MRS study
It is interesting that according to where tumors occur in the brainstem usually indicates what their histology and behavior is Although not absolute we know that tumors can have a very poor prognosis versus an extremely good prognosis depending on their location in the brainstem Yet there are always the cases that do not act in the typical fashion and this is where MRS can prove helpful
This study is being done to look at a region of the brain called the tectal plate in children This part of the brain can be involved by tumors Because of the location of the tectal plate it is usually very difficult and risky to get a biopsy tissue sample from this area Magnetic Resonance Spectroscopy MRS is a non-invasive imaging technique that can look at the chemical make up of the brain MRS may allow us to better understand the nature and behavior of these tumors However in order to understand disease in this area we need to look at the normal chemical make up of the brain in children without tectal plate tumors Healthy patients are being asked to participate as a normal volunteer We anticipate having a total of 10 to 12 normal volunteers in the MRS study
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None