Ignite Creation Date:
2024-05-05 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00222274
Status:
COMPLETED
Last Update Posted:
2015-02-09
First Post:
2005-09-15
Brief Title:
HRV Biofeedback in Fibromyalgia
Sponsor:
Rutgers The State University of New Jersey
Organization:
Rutgers The State University of New Jersey
Study Overview
Official Title:
A Pilot Study of the Efficacy of Biofeedback in Patients With Fibromyalgia Syndrome
Status:
COMPLETED
Status Verified Date:
2015-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A growing body of evidence suggests that the symptoms of many fibromyalgia syndrome FMS sufferers might be the result of an imbalance in one of the major stress response systems the autonomic nervous system Thus respiratory sinus arrhythmia RSA biofeedback which has shown promise in other conditions associated with an autonomic nervous system imbalance could be effective in FMS With the aid of sensors and computers biofeedback involves modifying andor learning how to control normally involuntary processes like blood pressure heart rate and the autonomic nervous system through relaxation and breathing The goal of this study is to test the effectiveness of a 10-session RSA biofeedback treatment for the symptoms of fibromyalgia Forty patients receiving the RSA biofeedback treatment will be compared to 40 patients receiving another form of biofeedback thought to be minimally helpful control group Later control group patients will also receive the RSA biofeedback treatment We will study improvement in symptoms like pain fatigue sleep disturbance and depression in the RSA biofeedback group and compare these improvements to those in the control group We will also assess whether these improvements persist over time and what if any changes in the autonomic nervous system result from the treatment
Detailed Description:
Eighty female patients between the ages of 18 and 65 will be recruited from the rheumatology clinic at the University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School UMDNJ-RWJMS Qualified participants are those who have a diagnosis of FMS from a board certified rheumatologist using the diagnostic criteria established by the American College of Rheumatology Because women account for over 85 of FMS patients only women will be included as subjects Excluded from participating will be women with any of the following medical conditions neurologic disease or brain injury stroke or cardiovascular disease serious pulmonary disease including asthma liver or kidney disease serious gastrointestinal disorders and major psychiatric conditions including psychoses bipolar disorder alcohol or drug abuse and eating disorders Also excluded will be women with a life threatening medical illness communicative disorder lack of fluency in English illiteracy cardiac arrhythmia or high frequency and low frequency waves that are indistinguishable or that interact Patients will be required to add no medications to their regimen during the study period approximately 5 to 7 months Based on the clinical judgment of the investigators patients may also be asked to withdraw from the study should they miss two or more consecutive biofeedback sessions
After reading and signing the informed consent all participants will receive a medical evaluation to confirm the diagnosis of FMS based on the criteria established by the American College of Rheumatology All participants will be evaluated by board certified rheumatologists affiliated with UMDNJ-Robert Wood Johnson Medical School and remain blind to participants group assignment This examination will include a baseline tender point count or TPI that will be used as an exploratory measure Next participants will be asked to return for an appointment at the Biofeedback Laboratory at UMDNJ-RWJMS Participants will be instructed to refrain from taking any caffeine or alcohol for twelve hours prior to this and all other sessions where physiologic measures are to be collected Before beginning physiologic measures assessment participants will complete the baseline outcome measures the Fibromyalgia Impact Questionnaire FIQ the McGill Pain Questionnaire MPQ the Pittsburgh Sleep Quality Inventory PSQI and the Beck Depression Inventory II BDI-II in a quiet private room
The first appointment at the Biofeedback Laboratory will consist of introducing the participant to the setting equipment and basic procedure of biofeedback To obtain baseline physiological measures we will take a 5-minute heart period recording and the other measures including blood pressure respiration and muscle tension For consistency across participants on all resting 5-minute heart period recordings a vanilla baseline task will be included The vanilla baseline is a minimally demanding color detection task shown to provide a stable baseline against which changes in response to experimental challenges can be measured The task involves the presentation of a 10 to 12 cm rectangle on a computer monitor that changes color every 10 seconds Six colors are presented randomly and with equal probability over the course of the baseline period Subjects are told beforehand to count the number of times the object changes back to a randomly determined initial color At the end of the task subjects are asked to report their count
All participants will also undergo a simple task for the assessment of orthostatic hypotension Orthostatic hypotension is defined as a decrease of at least 20 mmHg in systolic blood pressure when an individual moves from a supine to standing position This assessment will occur in the same lab where the biofeedback session occurs First both blood pressure and pulse will be recorded with the participant in a standing position This will serve as the first recording of BP and pulse measures Then the participant will be instructed to lie down completely flat on a floor mat supine position for 10 minutes Approximately three minutes after the participant goes from a supine to standing position both blood pressure and pulse will be once again recorded A stand-alone blood pressure device will be used to record these measures
Next using biofeedback all participants will be taught to breathe at their resonant frequency as described below Based on the literature we will consider the rate of breathing that produces the highest frequency peak to be the participants resonant frequency Finding the true resonant frequency is a complex task beyond the scope and resources of this pilot project Results from this analysis will advise matching participants on high frequencylow frequency rates
Group Assignment Participants will then be randomly assigned to the active treatment group or EEG biofeedback control group using a restricted randomization procedure controlling for age high frequencylow frequency rates and general health status Those assigned to the active treatment group will be given ten weekly training sessions in RSA biofeedback while those in the control group will receive ten weekly sessions of EEG biofeedback starting immediately All questionnaire and psychophysiological data collected at baseline will be repeated after the last training session 10 weeks later and at 3 months At the end of ten weeks the EEG biofeedback control group participants will be offered the opportunity to participate in the 10-session RSA biofeedback program and subsequent intervention-related assessments after the last biofeedback session 10th and at 3 months The Week 10 assessment taken at the conclusion of the EEG biofeedback treatment will serve as the control groups baseline to maintain 10-week pretestposttest consistency between groups EEG biofeedback subjects will be compensated only once if they choose to participate in the RSA biofeedback trial
EEG Biofeedback Condition Participants assigned to this condition will receive 10 sessions of EEG alpha biofeedback In each session 20 minutes of biofeedback will be delivered using a JJ I-330-C2 physiograph The participant will learn how to modify specific brainwave activity known as alpha In particular participants will be taught to increase amplitude of alpha in the range of 8-12 Hz Increased amplitude is this range is associated with relaxation and reduction of anxiety but not baroreflex gain Participants will also practice for two 20-minute periods daily using the same methods used to increase alpha found in lab sessions
RSA Biofeedback Condition The biofeedback will consist of 10 weekly sessions of training at the same time of day for each subject The details of the procedure for RSA biofeedback are described in Appendix A One single practitioner a certified biofeedback technician will provide the biofeedback following the aforementioned protocol In each session 20 minutes of biofeedback will be delivered using a JJ C-2 Physiograph The participant will be taught to breathe at her resonant frequency as a first step to training the individual how to produce maximal increases in amplitude of RSA During the first session we will measure heart rate oscillation amplitudes while the individual breathes for intervals of two minutes each at specific frequencies ranging between 4 and 7 breaths per minute respectively 4 45 5 55 6 65 and 7 breaths per minute We will provide a pacing stimulus for this purpose a light display that moves up and down on the computer screen at the target respiratory rate The participant will be instructed to breathe at the rate of that stimulus We will consider the frequency yielding the highest frequency peak on the moving Fourier analysis data collected and displayed by the C-2 physiograph to be the resonant frequency In subsequent sessions the individual will be given biofeedback for 20 minutes The participant will be instructed to practice breathing at her own resonant frequency for 20-minute periods twice daily for the next week Throughout training the individual will be cautioned to breathe shallowly and naturally in order to avoid hyperventilation
At the second session the participant will be directly given biofeedback for cardiac variability and instructed to increase the amplitude of heart rate fluctuations that occur in conjunction with respiration The feedback will be given in several forms One is using a beat-to-beat cardiotachometer display superimposed on a measure of respiratory activity taken from a strain gauge The participant will be instructed to breathe approximately in phase with heart rate changes with the goal of maximally increasing amplitude of RSA In another display the participant will be shown a moving frequency analysis of heart rate within the band of 005-4 Hz The display will be updated approximately every second and reflects the frequency of heart rate fluctuations within the past 30 seconds The participant will be instructed to increase the spectral power peak that occurred at approximately resonant frequency At the beginning and end of this and every biofeedback session participants will be asked to rate their pain muscle stiffness fatigue mood and cognitive processes memory and concentration on a verbal scale of one to ten
In the third session a stand-alone device will be provided for home practice HeartMath Freeze Framer This system analyzes heart rhythms and provides a display sensitive to changes A colorful game format is used to reward the user for increases in heart rate coherence which in turn will maximize amplitude of RSA Participants will be instructed to practice for two 20-minute sessions per day and note in the log included with the HeartMath Freeze Framer instructions whether or not they practiced each day the length of each practice session and any questions or observations
Biofeedback Data Collection Procedure At sessions 1 10 and at 3 months a resting 5-minute heart period using the vanilla task will be obtained before commencing biofeedback and at the end of the session During biofeedback two 5-minute heart period recordings will be taken one at the beginning of the session and one at the end Questionnaire data will then be collected Patients will be given a 25 payment for participation at the end of each data collection session for a total of 75
After reading and signing the informed consent all participants will receive a medical evaluation to confirm the diagnosis of FMS based on the criteria established by the American College of Rheumatology All participants will be evaluated by board certified rheumatologists affiliated with UMDNJ-Robert Wood Johnson Medical School and remain blind to participants group assignment This examination will include a baseline tender point count or TPI that will be used as an exploratory measure Next participants will be asked to return for an appointment at the Biofeedback Laboratory at UMDNJ-RWJMS Participants will be instructed to refrain from taking any caffeine or alcohol for twelve hours prior to this and all other sessions where physiologic measures are to be collected Before beginning physiologic measures assessment participants will complete the baseline outcome measures the Fibromyalgia Impact Questionnaire FIQ the McGill Pain Questionnaire MPQ the Pittsburgh Sleep Quality Inventory PSQI and the Beck Depression Inventory II BDI-II in a quiet private room
The first appointment at the Biofeedback Laboratory will consist of introducing the participant to the setting equipment and basic procedure of biofeedback To obtain baseline physiological measures we will take a 5-minute heart period recording and the other measures including blood pressure respiration and muscle tension For consistency across participants on all resting 5-minute heart period recordings a vanilla baseline task will be included The vanilla baseline is a minimally demanding color detection task shown to provide a stable baseline against which changes in response to experimental challenges can be measured The task involves the presentation of a 10 to 12 cm rectangle on a computer monitor that changes color every 10 seconds Six colors are presented randomly and with equal probability over the course of the baseline period Subjects are told beforehand to count the number of times the object changes back to a randomly determined initial color At the end of the task subjects are asked to report their count
All participants will also undergo a simple task for the assessment of orthostatic hypotension Orthostatic hypotension is defined as a decrease of at least 20 mmHg in systolic blood pressure when an individual moves from a supine to standing position This assessment will occur in the same lab where the biofeedback session occurs First both blood pressure and pulse will be recorded with the participant in a standing position This will serve as the first recording of BP and pulse measures Then the participant will be instructed to lie down completely flat on a floor mat supine position for 10 minutes Approximately three minutes after the participant goes from a supine to standing position both blood pressure and pulse will be once again recorded A stand-alone blood pressure device will be used to record these measures
Next using biofeedback all participants will be taught to breathe at their resonant frequency as described below Based on the literature we will consider the rate of breathing that produces the highest frequency peak to be the participants resonant frequency Finding the true resonant frequency is a complex task beyond the scope and resources of this pilot project Results from this analysis will advise matching participants on high frequencylow frequency rates
Group Assignment Participants will then be randomly assigned to the active treatment group or EEG biofeedback control group using a restricted randomization procedure controlling for age high frequencylow frequency rates and general health status Those assigned to the active treatment group will be given ten weekly training sessions in RSA biofeedback while those in the control group will receive ten weekly sessions of EEG biofeedback starting immediately All questionnaire and psychophysiological data collected at baseline will be repeated after the last training session 10 weeks later and at 3 months At the end of ten weeks the EEG biofeedback control group participants will be offered the opportunity to participate in the 10-session RSA biofeedback program and subsequent intervention-related assessments after the last biofeedback session 10th and at 3 months The Week 10 assessment taken at the conclusion of the EEG biofeedback treatment will serve as the control groups baseline to maintain 10-week pretestposttest consistency between groups EEG biofeedback subjects will be compensated only once if they choose to participate in the RSA biofeedback trial
EEG Biofeedback Condition Participants assigned to this condition will receive 10 sessions of EEG alpha biofeedback In each session 20 minutes of biofeedback will be delivered using a JJ I-330-C2 physiograph The participant will learn how to modify specific brainwave activity known as alpha In particular participants will be taught to increase amplitude of alpha in the range of 8-12 Hz Increased amplitude is this range is associated with relaxation and reduction of anxiety but not baroreflex gain Participants will also practice for two 20-minute periods daily using the same methods used to increase alpha found in lab sessions
RSA Biofeedback Condition The biofeedback will consist of 10 weekly sessions of training at the same time of day for each subject The details of the procedure for RSA biofeedback are described in Appendix A One single practitioner a certified biofeedback technician will provide the biofeedback following the aforementioned protocol In each session 20 minutes of biofeedback will be delivered using a JJ C-2 Physiograph The participant will be taught to breathe at her resonant frequency as a first step to training the individual how to produce maximal increases in amplitude of RSA During the first session we will measure heart rate oscillation amplitudes while the individual breathes for intervals of two minutes each at specific frequencies ranging between 4 and 7 breaths per minute respectively 4 45 5 55 6 65 and 7 breaths per minute We will provide a pacing stimulus for this purpose a light display that moves up and down on the computer screen at the target respiratory rate The participant will be instructed to breathe at the rate of that stimulus We will consider the frequency yielding the highest frequency peak on the moving Fourier analysis data collected and displayed by the C-2 physiograph to be the resonant frequency In subsequent sessions the individual will be given biofeedback for 20 minutes The participant will be instructed to practice breathing at her own resonant frequency for 20-minute periods twice daily for the next week Throughout training the individual will be cautioned to breathe shallowly and naturally in order to avoid hyperventilation
At the second session the participant will be directly given biofeedback for cardiac variability and instructed to increase the amplitude of heart rate fluctuations that occur in conjunction with respiration The feedback will be given in several forms One is using a beat-to-beat cardiotachometer display superimposed on a measure of respiratory activity taken from a strain gauge The participant will be instructed to breathe approximately in phase with heart rate changes with the goal of maximally increasing amplitude of RSA In another display the participant will be shown a moving frequency analysis of heart rate within the band of 005-4 Hz The display will be updated approximately every second and reflects the frequency of heart rate fluctuations within the past 30 seconds The participant will be instructed to increase the spectral power peak that occurred at approximately resonant frequency At the beginning and end of this and every biofeedback session participants will be asked to rate their pain muscle stiffness fatigue mood and cognitive processes memory and concentration on a verbal scale of one to ten
In the third session a stand-alone device will be provided for home practice HeartMath Freeze Framer This system analyzes heart rhythms and provides a display sensitive to changes A colorful game format is used to reward the user for increases in heart rate coherence which in turn will maximize amplitude of RSA Participants will be instructed to practice for two 20-minute sessions per day and note in the log included with the HeartMath Freeze Framer instructions whether or not they practiced each day the length of each practice session and any questions or observations
Biofeedback Data Collection Procedure At sessions 1 10 and at 3 months a resting 5-minute heart period using the vanilla task will be obtained before commencing biofeedback and at the end of the session During biofeedback two 5-minute heart period recordings will be taken one at the beginning of the session and one at the end Questionnaire data will then be collected Patients will be given a 25 payment for participation at the end of each data collection session for a total of 75
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None