Ignite Creation Date:
2024-05-05 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00229255
Status:
COMPLETED
Last Update Posted:
2012-06-01
First Post:
2005-09-27
Brief Title:
Relation of Obesity With Frequency of Meals MST 0557
Sponsor:
Rockefeller University
Organization:
Rockefeller University
Study Overview
Official Title:
Relation of Obesity With Frequency of Meals MST 0557
Status:
COMPLETED
Status Verified Date:
2012-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to test the relationship between frequency of meals and hepatic fat content and insulin sensitivity We the researchers at Rockefeller University hypothesize that low plasma insulin levels as achieved by periods of fasting will prevent insulin resistance and reduce hepatic lipid content In contrast frequent carbohydrate-rich meals will predispose to hepatic steatosis non-alcoholic and insulin resistance
This is a 6 week inpatient study
This is a 6 week inpatient study
Detailed Description:
The hypothesis will be tested by studying two groups of normal subjects who will receive a defined weight maintenance diet one group will be given meals twice a day and other group will be given eight meals snacks per day At the beginning of the study period and after 4 weeks following the specified frequency of meals the study subjects will have their whole body insulin sensitivity and hepatic fat content measured by the euglycemic-hyperinsulinemic clamp and MRI of the liver respectively
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None