Ignite Creation Date:
2024-05-05 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00226694
Status:
COMPLETED
Last Update Posted:
2014-01-07
First Post:
2005-09-23
Brief Title:
Alcohol and Gender Effects on Stress Circuit Function
Sponsor:
University of Cincinnati
Organization:
University of Cincinnati
Study Overview
Official Title:
Alcohol and Gender Effects on Stress Circuit Function
Status:
COMPLETED
Status Verified Date:
2014-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to look at the stress hormone response to medication-induced stress and a placebo an inactive compound in non-drinking recovering male and female alcoholics with a specific emphasis on the differences between men and women in the two recovering alcoholic groups
Detailed Description:
Women and men differ in the ways stress affects the development and maintenance of alcoholism However no published studies in alcohol dependent patients have examined sex differences in stress responsiveness that most likely mediate these effects and influence the clinical course and treatment of the disorder
The long-range goal of this research program is to define aspects of the neural genetic and environmental mechanisms differentially regulating the stress response in alcohol dependent women and men The proposed study extends prior work revealing sex-dependent alterations in basal and serotonin-induced stress hormone concentrations in abstinent alcoholics Our central hypothesis is that sex differences in serotonin function or HPA sensitivity conspire with genetically influenced alterations in serotonin signaling to produce maladaptive stress responses in some alcoholic women These altered stress responses may serve as the target of novel sex-specific pharmacotherapies
The long-range goal of this research program is to define aspects of the neural genetic and environmental mechanisms differentially regulating the stress response in alcohol dependent women and men The proposed study extends prior work revealing sex-dependent alterations in basal and serotonin-induced stress hormone concentrations in abstinent alcoholics Our central hypothesis is that sex differences in serotonin function or HPA sensitivity conspire with genetically influenced alterations in serotonin signaling to produce maladaptive stress responses in some alcoholic women These altered stress responses may serve as the target of novel sex-specific pharmacotherapies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIH R01 AA013307-01 | US NIH GrantContract | None | httpsreporternihgovquickSearchR01AA013307 |
| R01AA013307 | NIH | None | None |