Ignite Creation Date:
2024-05-05 @ 12:04 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00232388
Status:
TERMINATED
Last Update Posted:
2015-10-07
First Post:
2005-10-03
Brief Title:
Association of PICP Serum Marker in Patients With LVSD
Sponsor:
Texas Tech University Health Sciences Center
Organization:
Texas Tech University Health Sciences Center
Study Overview
Official Title:
Phase 1 Study of PICP Serum Marker of Myocardial Fibrosis and Diastolic Function in Patients With Systolic Dysfunction
Status:
TERMINATED
Status Verified Date:
2015-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
PI left institution Data collected from 45 participants but no results are available
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine if the carboxy-terminal of procollagen type I PICP can be a useful marker of different degrees of myocardial fibrosis
Detailed Description:
Abnormality of diastolic function particularly a more advanced form known as restrictive tilling pattern has been correlated with worse outcome in patients with systolic dysfunction associated with chronic heart failure or following an acute myocardial infarction Recently the severity of diastolic dysfunction has also been shown to predict the response to cardiac synchronization therapy for refractory heart failure due to systolic dysfunction
Varying degree of diastolic dysfunction has been reported among patients with comparable severity of systolic dysfunction The underlying mechanisms responsible for the observed discordance between systolic and diastolic dysfunction in these patients remains incompletely understood
The carboxy-terminal of procollagen type I PICP a peptide that is cleaved from procollagen type I during the synthesis of fibril-forming collagen type I has been associated with myocardial fibrosis Myocardial fibrosis is a major determinant of both systolic and diastolic function of the heart We hypothesize that differential degrees of myocardial fibrosis may be responsible for these discrepancies
Varying degree of diastolic dysfunction has been reported among patients with comparable severity of systolic dysfunction The underlying mechanisms responsible for the observed discordance between systolic and diastolic dysfunction in these patients remains incompletely understood
The carboxy-terminal of procollagen type I PICP a peptide that is cleaved from procollagen type I during the synthesis of fibril-forming collagen type I has been associated with myocardial fibrosis Myocardial fibrosis is a major determinant of both systolic and diastolic function of the heart We hypothesize that differential degrees of myocardial fibrosis may be responsible for these discrepancies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None